1--alkyl-glycerols from Squid Reduce Inflammation and Modify Fatty Acid and Plasmalogen Metabolism in Asthma Associated with Obesity.

Asthma associated with obesity is considered the most severe phenotype and can be challenging to manage with standard medications. Marine-derived 1--alkyl-glycerols (AGs), as precursors for plasmalogen synthesis, have high biological activity, making them a promising substance for pharmacology. This study aimed to investigate the effect of AGs from squid on lung function, fatty acid and plasmalogen levels, and cytokine and adipokine production in obese patients with asthma.

The Effect of Copper on the Microstructure, Wear and Corrosion Resistance of CoCrCuFeNi High-Entropy Alloys Manufactured by Powder Metallurgy.

This paper focuses on the microstructure, phase composition, mechanical, tribological and corrosion properties of high-entropy alloys (HEAs) in the CoCrCuFeNi system depending on copper content, which was varied from 0 to 20 at. % with an increment of 5%. CoCrCuFeNi alloys were manufactured by powder metallurgy methods: mechanical alloying and hot pressing of element mixtures.

[Predictors of dysfunction of the small respiratory tract in patients with asthma].

Aim: To identify predictors of development of small respiratory tract (SRT) dysfunction in patients with asthma of mild severity, partially controlled course.

Materials And Methods: One hundred and fourteen patients with asthma of mild severity, partially controlled course, were examined. The control group consisted of 27 healthy volunteers.

[The pathophysiological role of adipokines in the development of bronchial asthma combined with obesity].

The combined course of bronchial asthma (BA) and obesity is one of the urgent medical and social problems that requires a comprehensive and careful study in connection with a decrease in the quality of life of such patients, an increase in the frequency, duration of hospitalization and a high economic burden for the state as a whole. The relationship between BA and obesity is now confirmed by numerous studies, at the same time, despite the variability of the proposed mechanisms of pathogenetic effects of obesity on asthma, metabolic aspects of the relationship of these diseases need further study. Adipose tissue hormones are responsible for the energy homeostasis of the body therefore, excessive accumulation of adipose tissue is accompanied by the development of an imbalance in metabolic processes in various organs and tissues.

Lipid-Induced Mechanisms of Metabolic Syndrome.

Metabolic syndrome (MetS) has a worldwide tendency to increase and depends on many components, which explains the complexity of diagnosis, approaches to the prevention, and treatment of this pathology. Insulin resistance (IR) is the crucial cause of the MetS pathogenesis, which develops against the background of abdominal obesity. In light of recent evidence, it has been shown that lipids, especially fatty acids (FAs), are important signaling molecules that regulate the signaling pathways of insulin and inflammatory mediators.