Publications by authors named "M W A van Geldorp"
Article Synopsis
- The study explores the experiences and needs of informal caregivers (ICs) involved in shared decision-making (SDM) for patients over 70 with severe aortic stenosis (AS).
- It found that while most ICs prefer to be collaborative partners in decision-making, they often feel overlooked by healthcare professionals when it comes to discussing the patient's daily life.
- Higher perceived involvement in SDM is linked to better quality of life and lower distress for ICs, emphasizing the need for professionals to actively include them in the decision-making process.
Article Synopsis
- Intracellular calcium overload contributes to heart dysfunction, and understanding how to regulate calcium levels could help develop better heart failure therapies.
- The transcription factor ZEB2, induced by HIF1α in low-oxygen conditions, helps manage genes related to calcium handling and heart contraction, thus protecting against heart issues.
- ZEB2 enhances calcium uptake by increasing phosphorylation of phospholamban, while also reducing harmful signaling that leads to heart remodeling, making it a key player in maintaining heart function.
An increasing number of breast cancer patients develop brain metastases (BM). Standard-of-care treatments are largely inefficient, and breast cancer brain metastasis (BCBM) patients are considered untreatable. Immunotherapies are not successfully employed in BCBM, in part because breast cancer is a "cold" tumor and also because the brain tissue has a unique immune landscape.
View Article and Find Full Text PDFWe have presented a case of a ruptured descending aortic aneurysm that was accompanied by extreme tortuosity and a pseudocoarctation at the level of the ligamentum arteriosum. We performed successful endovascular repair, covering the left subclavian artery, using a transapical-to-femoral artery (through-and-through) guidewire technique to overcome the tortuosity, with the option to perform balloon angioplasty in the case of an increased gradient over the coarctation. In the present case report, we have underlined the role of close collaborations with aortic expertise centers.
View Article and Find Full Text PDFAim: To provide insight into the basic characteristics of decision making in the treatment of symptomatic severe aortic stenosis (SSAS) in Dutch heart centres with specific emphasis on the evaluation of frailty, cognition, nutritional status and physical functioning/functionality in (instrumental) activities of daily living [(I)ADL].
Methods: A questionnaire was used that is based on the European and American guidelines for SSAS treatment. The survey was administered to physicians and non-physicians in Dutch heart centres involved in the decision-making pathway for SSAS treatment.