Evolution of Water State in the "Ionic Liquid EAN/Al(NO)/HO" System Depending on Temperature and Aluminum Salt Concentration.

Although lithium salts are the most successful materials for electrochemical devices so far, there is growing interest in electrolytes containing divalent and trivalent salts, which are characterized by a much higher energy density than lithium systems. For this purpose, the physical and chemical properties of solutions of aluminum nitrate in ethylammonium nitrate (EAN) were studied in a number of works. However, it was demonstrated by the H NMR method that solutions contain water (from aluminum crystallohydrates) in the first solvated shell of the Al cation even after usual drying procedures, and this solvated water cannot be directly detected by the standard Karl Fischer analysis.

Modulation of Albumin Esterase Activity by Warfarin and Diazepam.

Data are accumulating on the hydrolytic activity of serum albumin towards esters and organophosphates. Previously, with the help of the technology of proton nuclear magnetic resonance (H NMR) spectroscopy, we observed the yield of acetate in the solution of bovine serum albumin and -nitrophenyl acetate (NPA). Thus, we showed that albumin possesses true esterase activity towards NPA.

Cyclizations of Alkenyl(Alkynyl)-Functionalized Quinazolinones and their Heteroanalogues: A Powerful Strategy for the Construction of Polyheterocyclic Structures.

Quinazolin-4-one, its heteroanalogues, and derivatives represent an outstandingly important class of compounds in modern organic, medicinal, and pharmaceutical chemistry, as these molecular structures are noted for their wide synthetic and pharmacological potential. In the last years, ever-increasing research attention has been paid to quinazolinone derivatives bearing alkenyl and alkynyl substituents on the pyrimidinone nucleus. The original structural combination of synthetically powerful endocyclic amidine (or amidine-related) and exocyclic unsaturated moieties provides a driving force for cyclizations, which offer an efficient toolkit to construct a variety of fused pyrimidine systems with saturated N- and N,S-heterocycles.

The State of Water in "Ionic Liquid [bmim]Cl/AlCl/HO" Systems.

The unique physical and chemical properties of ionic liquids (ILs) determine their numerous applications in "green" chemistry and material science. Recently, systems based on ILs have been considered to be promising for use in a new generation of electrochemical devices. The results of a nuclear magnetic resonance (NMR) study of the microstructure of 1-butyl-3-methylimidazolium chloride (IL)/water mixtures in the presence of Al cations are presented.

Pd-catalyzed oxidative amination of 2-alkenylquinazolin-4(3)-ones: synthesis of methylene and vinyl derivatives of pyrrolo(pyrido)[2,1-]quinazolinones.

When treated with the catalytic system Pd(OAc)/PPh/CsCO/benzoquinone in dioxane or Pd(PPh)Cl/-BuONa/CsCO/benzoquinone in toluene, 2-butenylquinazolin-4(3)-ones undergo intramolecular aza-Wacker cyclization to give methylene-substituted pyrrolo(pyrido)[2,1-]quinazolinones. The latter catalytic system is also efficient in the reaction of pentenyl(hexenyl)quinazolin-4(3)-ones but, in these cases, the aminopalladation of C-H multiple bonds significantly competed with allylic C(sp)-H bond activation which leads to hitherto unknown vinyl-substituted pyrrolo(pyrido)[2,1-]quinazolinones.