Cardiac arrhythmias in fish induced by natural and anthropogenic changes in environmental conditions.

A regular heartbeat is essential for maintaining the homeostasis of the vertebrate body. However, environmental pollutants, oxygen deficiency and extreme temperatures can impair heart function in fish. In this Review, we provide an integrative view of the molecular origins of cardiac arrhythmias and their functional consequences, from the level of ion channels to cardiac electrical activity in living fish.

Species-specific differences and temperature-dependence of Na/K-ATPase in freshwater mussels Anodonta anatina and Unio tumidus (Bivalvia: Unionidae).

The predicted global warming of surface waters can be challenging to aquatic ectotherms like freshwater mussels. Especially animals in northern temperate latitudes may face and physiologically acclimate to significant stress from seasonal temperature fluctuations. Na/K-ATPase enzyme is one of the key mechanisms that allow mussels to cope with changing water temperatures.

Dual effect of polyaromatic hydrocarbons on sarco(endo)plasmic reticulum calcium ATPase (SERCA) activity of a teleost fish (Oncorhynchus mykiss).

Polycyclic aromatic hydrocarbons (PAHs) are embryo- and cardiotoxic to fish that might be associated with improper intracellular Ca management. Since sarco(endo)plasmic reticulum Ca-ATPase (SERCA) is a major regulator of intracellular Ca, the SERCA activity and the contractile properties of rainbow trout (Oncorhynchus mykiss) ventricle were measured in the presence of 3- and 4-cyclic PAHs. In unfractionated ventricular homogenates, acute exposure of SERCA to 0.

Three steps down: Metabolic depression in winter-acclimatized crucian carp (Carassius carassius L.).

Acclimatization of certain ectothermic vertebrates to winter conditions is associated with reduced energy consumption (winter dormancy). Principally, this may be achieved by reducing movement activity, depression of basal cellular functions, or by switching from aerobic to anaerobic energy production to sustain low energy consumption during anoxia. Therefore, we determined standard (SMR), routine (RMR) and anoxic (AMR) metabolic rates in summer- (SumA; 20 °C) and winter-acclimatized (WinA; 2 °C) crucian carp (Carassius carassius), an anoxia-tolerant teleost fish.

B-cell receptor reactivity against in nodular lymphocyte-predominant Hodgkin lymphoma.

Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a Hodgkin lymphoma expressing functional B-cell receptors (BCR). Recently, we described a dual stimulation model of IgD+ lymphocyte-predominant cells by Moraxella catarrhalis antigen RpoC and its superantigen MID/hag, associated with extralong CDR3 and HLA-DRB1*04 or HLADRB1* 07 haplotype. The aim of the present study was to extend the antigen screening to further bacteria and viruses.