Lung transplant patients often suffer from posttransplant airway pathologies that require placement of endobronchial stents. In addition to surveillance bronchoscopy, patients often undergo radiographic stent evaluations. Chest x-rays are extremely limited in their ability to diagnose stent complications, so many patients require chest computed tomography (CT) scans for stent evaluation.
View Article and Find Full Text PDFInfectious peritonitis is a common complication in patients undergoing chronic peritoneal dialysis (PD), limiting the duration of PD as a modality for renal replacement therapy and increasing patient morbidity and mortality. Antimicrobial peptides (AMPs) serve critical roles in mucosal defense, but their expression and activity during peritonitis are poorly understood. We hypothesized that AMPs belonging to the Ribonuclease (RNase) A Superfamily are present in peritoneal fluid and increase during peritonitis in patients undergoing chronic PD.
View Article and Find Full Text PDFRecent evidence indicates that antimicrobial peptides (AMPs) serve key roles in defending the urinary tract against invading uropathogens. To date, the individual contribution of AMPs to urinary tract host defense is not well defined. In this study, we identified Regenerating islet-derived 3 gamma (RegIIIγ) as the most transcriptionally up-regulated AMP in murine bladder transcriptomes following uropathogenic Escherichia coli (UPEC) infection.
View Article and Find Full Text PDFThe surgical workforce is ageing. This will impact on future workforce supply and planning, as well as the professional performance and welfare of surgeons themselves. This paper is a 'call to arms' to surgeons to consider the complex problem of advancing years and surgical performance.
View Article and Find Full Text PDFBackground: Although the borderline personality disorder severity index--version IV (BPDSI-IV) has already been used in several studies, psychometric properties are only known from two developing studies.
Sampling And Methods: To examine item characteristics, reliability, and validity indicators, a large sample including subjects with borderline personality disorder (n = 163), a mixed psychiatric group (n = 58), and a healthy control group (n = 43) were interviewed with the German version of the Structured Clinical Interview for DSM-IV Personality Disorders (SCID-II) as well as the BPDSI-IV.
Results: The indices for interrater reliability as well as internal consistency of the BPDSI-IV were excellent to good.