Publications by authors named "M Voldoire"
Article Synopsis
- - The study investigates the role of a specific oncofetal protein as a potential biomarker for chronic myeloid leukemia (CML), which is a cancer affecting blood-forming cells caused by genetic changes.
- - Researchers employed various techniques, including cell culture and ELISA, to demonstrate that this protein is overexpressed in CML patients and may be linked to the disease's progression and severity.
- - Findings indicate that the protein is upregulated in a kinase-dependent way and may significantly contribute to the mechanisms driving leukemogenesis in CML.
Article Synopsis
- The BCR-ABL oncogene, linked to chronic myeloid leukemia (CML), activates various signaling pathways in leukemic cells, leading to treatment challenges like resistance to tyrosine kinase inhibitors (TKIs) and disease progression.
- A study using a BCR-ABL-expressing UT-7 cell line identified over 2000 genes with altered expression, with ETS1 being the most significantly upregulated, indicating its role in CML.
- Increased ETS1 mRNA levels were found in CML patient blood samples, and certain genes related to ETS1 expression were associated with poor response to imatinib therapy, highlighting ETS1's potential impact on disease progression and treatment outcomes.
Objective: The role of allogenic stem cell transplantation (ASCT) is still debated in myelofibrosis (MF).
Methods: A retrospective analyzed was performed to compare the outcome of 71 patients with intermediate-2 or high-risk Dynamic International Prognosis Scoring System+ (DIPSS+) primary (PMF) or secondary (SMF) myelofibrosis with an indication of ASCT as they ultimately underwent the procedure (n=34) or not (n=37).
Results: Five-year overall survival (OS) was not statistically different between both groups (allograft: 52% vs no allograft: 34%, P=.