Atypical fibroxanthoma arising in an area of syringocystadenoma papilliferum associated with nevus sebaceus: positivity of the atypical fibroxanthoma component for CD31.

The occurrence of an atypical fibroxanthoma in association with a syringocystadenoma papilliferum is reported. Both neoplasms showed characteristic histologic features and displayed typical immunohistochemical profiles. The neoplasms developed in intimate admixture in an area of nevus sebaceus.

Spindle cell hemangioma and epithelioid hemangioendothelioma arising in an area of lymphedema.

We report the case of a 73-year-old female patient with a multifocal vascular tumor that we regard as composite hemangioendothelioma (CHE). The lesions developed in an area of lymphedema. CHEs are rare vascular tumors in which various types of hemangioendothelioma are combined in 1 lesion.

Successful treatment of anogenital Bowen's disease with the immunomodulator imiquimod, and monitoring of therapy by DNA image cytometry.

Imiquimod (Aldara, 3M) is an immune response modifier used for the treatment of anogenital warts. We report a 55-year-old non-immunocompromised woman with extensive, human papillomavirus (HPV) 16-positive anogenital Bowen's disease. After 5 months of local treatment with imiquimod, the lesions completely regressed clinically and histologically, and HPV 16 DNA was no longer detectable.

Differentiation between malignant and benign follicular adnexal tumours of the skin by DNA image cytometry.

Background: We have demonstrated in previous studies that DNA image cytometry (DNA ICM) can be helpful in detecting malignancy in sebaceous tumours of the Muir-Torre syndrome and sweat gland tumours. However, little is known about DNA ICM in cutaneous adnexal tumours with follicular differentiation.

Objectives: To study a larger series of benign and malignant follicular adnexal tumours with DNA ICM.

Tissue eosinophilia in acute and chronic atopic dermatitis: a morphometric approach using quantitative image analysis of immunostaining.

Background: The frequency and amount of tissue eosinophilia in spontaneous lesions of acute and chronic atopic dermatitis (AD) are still a matter of controversy, and little is known about the distribution of eosinophilia in skin.

Objectives: To give a quantitative description of tissue eosinophilia in spontaneous lesions of acute and chronic AD based on morphometric data.

Methods: Thirty-one lesional skin biopsies of AD were evaluated using our recently described method for the quantitative assessment of eosinophilic granule protein (EGP) deposition by image analysis of immunostaining using the antibodies EG1, EG2, MBP, EPO and neutrophil elastase (NE).