Complete hepatic caudate lobe resection: is robotic approach safe? Report from experienced centers.

Minimally invasive liver surgery has become widely accepted as a safe and effective approach, especially with experienced surgeons. Robotic hepatectomy may offer significant benefits in challenging procedures like caudate lobe resection. The caudate lobe's intricate anatomy and deep-seated location make its resection particularly challenging, with limited reports on minimally invasive techniques.

propofol permeation across nasal mucosa: A proof-of-concept study for outpatient light sedation via nasal route.

Background And Purpose: Aiming to achieve light sedation via intranasal administration, this study showed that propofol (PPF) did not permeate across the rabbit nasal mucosa ex vivo from its marketed emulsion for injection.

Experimental Approach: Dilution of the emulsion with methyl-β-cyclodextrin in saline solution increased propofol solubility in water and diffusion across the nasal epithelium.

Key Results And Conclusion: Despite these positive effects of the cyclodextrin, the amount of PPF permeated was minimal in 3 h, exceeding the formulation residence time in the nose.

Ecotoxicity and Mutagenicity Assessment of Novel Antifungal Agents VT-1161 and T-2307.

Antifungal substances are essential for managing fungal infections in humans, animals, and plants, and their usage has significantly increased due to the global rise in fungal infections. However, the extensive application of antifungal agents in pharmaceuticals, personal care products, and agriculture has led to their widespread environmental dissemination through various pathways, such as excretion, improper disposal, and agricultural runoff. Despite advances in wastewater treatment, many antifungal compounds persist in the environment, affecting non-target organisms and contributing to resistance development.

A multi-disciplinary approach based on chemical characterization of foreshore sediments, ecotoxicity assessment and statistical analyses for environmental monitoring of marine-coastal areas.

The present work aims at providing a multi-disciplinary approach for environmental monitoring in marine-coastal areas. A monitoring campaign of 13 months (October 2022-October 2023) was carried out on sandy foreshore sediments (SFSs). The SFSs were analysed for potentially toxic elements (PTEs) and rare earth elements (REEs) content determination.