Definition of an Inflammatory Biomarker Signature in Plasma-Derived Extracellular Vesicles of Glioblastoma Patients.

Glioblastoma (GB) is an aggressive type of tumour for which therapeutic options and biomarkers are limited. GB diagnosis mostly relies on symptomatic presentation of the tumour and, in turn, brain imaging and invasive biopsy that can delay its diagnosis. Description of easily accessible and effective biomarkers present in biofluids would thus prove invaluable in GB diagnosis.

Second surgery for progressive glioblastoma: a multi-centre questionnaire and cohort-based review of clinical decision-making and patient outcomes in current practice.

Purpose: Glioblastoma prognosis is poor. Treatment options are limited at progression. Surgery may benefit, but no quality guidelines exist to inform patient selection.

Indolocarbazole based polymer coated super adsorbent polyurethane sponges for oil/organic solvent removal.

The synthesis of an indolocarbazole-fluorene based conjugated polymer (ICZP6), by Sonogashira coupling reaction, has been presented. The ICZP6 has then been integrated with a nano iron oxide embedded polyurethane foam (ICZP6PUF) to develop a promising adsorbent for oil/organic contaminants in aqueous systems. The anchoring ability of ICZP6 on to iron oxide PU sponge switches on significant hydrophobicity within the whole molecular assembly.

Cell-derived extracellular vesicles can be used as a biomarker reservoir for glioblastoma tumor subtyping.

Glioblastoma (GBM) is one of the most aggressive solid tumors for which treatment options and biomarkers are limited. Small extracellular vesicles (sEVs) produced by both GBM and stromal cells are central in the inter-cellular communication that is taking place in the tumor bulk. As tumor sEVs are accessible in biofluids, recent reports have suggested that sEVs contain valuable biomarkers for GBM patient diagnosis and follow-up.