Publications by authors named "M Vindigni"
Background/objectives: Ventriculoperitoneal shunting is a validated procedure for the treatment of idiopathic normal-pressure hydrocephalus. To select shunt-responsive patients, infusion and tap tests can be used. Only gait is evaluated after the procedure to establish a potential improvement.
View Article and Find Full Text PDFGlioblastoma Multiforme (GBM) is the most aggressive primary tumor of the Central Nervous System (CNS) with a low survival rate. The malignancy of GBM is sustained by a bidirectional crosstalk between tumor cells and the Tumor Microenvironment (TME). This mechanism of intercellular communication is mediated, at least in part, by the release of exosomes.
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- Long-standing overt ventriculomegaly in adults (LOVA) can cause cognitive deficits, but studies on its cognitive impact and the effectiveness of endoscopic third ventriculostomy (ETV) are limited.
- In a study with 23 LOVA patients, cognitive assessments before, after, and five months following ETV revealed selective long-term memory and visuospatial skill deficits, but no overall cognitive decline.
- ETV surgery led to significant improvements in these areas, particularly in patients with higher premorbid IQ, suggesting that cognitive reserve plays a crucial role in brain plasticity and recovery following surgery.
Purpose: To determine the relationship between intravoxel incoherent motion (IVIM) MRI parameters and clinical changes post-tap test (TT) in idiopathic normal-pressure hydrocephalus (iNPH) patients.
Methods: Forty-four probable iNPH patients underwent 3 T MRI before and after TT. IVIM parameters were calculated from eight different bilateral regions of interest in basal ganglia, centrum semiovale, and corona radiata.