Publications by authors named "M Villani"
Neuroblastoma (NB) is the most common extracranial solid tumor in children, with variable outcomes ranging from spontaneous remission to high-risk cases often leading to relapse or refractory disease. Approximately 50% of patients with NB have high-risk features, often experiencing relapse or refractory disease despite intensive treatments and the prognosis remains poor, with long-term event-free survival (EFS) rates below 10%,Radioactive iodine-labeled meta-iodobenzylguanidine (¹³¹I-mIBG) therapy, leveraging NB cells' radiosensitivity and expression of the norepinephrine transporter (NET), has shown promise in treating relapsed or refractory NB. Since 1985, ¹³¹I-mIBG has been studied to determine the maximum tolerated dose and side effects, with recent trials exploring its use in front-line treatment.
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- - Exoskeletons are increasingly used for helping children with neurological disorders improve their gait, but evaluating their effectiveness remains complex due to impacts on sensorimotor interactions and potential gait abnormalities.
- - This study explored how a specific exoskeleton affected muscle activity and spinal motor output in children during gait rehabilitation, focusing on the neuromechanics involved.
- - Results indicated that even at slower walking speeds, muscle activation levels during exoskeleton use were similar to normal walking, suggesting that children's locomotor systems actively engaged during exoskeleton-assisted stepping.
This paper presents a comprehensive study of hydrogenated amorphous silicon (a-Si)-based detectors, utilizing electrical characterization, Raman spectroscopy, photoemission, and inverse photoemission techniques. The unique properties of a-Si have sparked interest in its application for radiation detection in both physics and medicine. Although amorphous silicon (a-Si) is inherently a highly defective material, hydrogenation significantly reduces defect density, enabling its use in radiation detector devices.
View Article and Find Full Text PDFObjective: Children with acute hematogenous osteomyelitis (AHO) from methicillin-resistant Staphylococcus aureus (MRSA) are treated with vancomycin despite the risk of acute kidney injury (AKI). This study evaluates the rate of AKI and resource utilization for children with or without AKI when vancomycin is used in this setting.
Methods: Children with MRSA AHO treated with vancomycin were retrospectively studied.