Primaty cutaneous histoplasmosis.

A 29-year old woman presented with diffuse swelling of the base of the right thumb along with ulceration. X-ray indicated bony damage. Histopathology showed PAS positive intracellular organisms suggestive of histoplasmosis.

Hansen's disease with bilateral tarsal disorganisation.

A 37-year old male patient with Hansen's disease midborderline spectrum, presented with bilateral pedal edema. X-ray examination of the feet showed disorganisation and disintegration of the tarsal bones. Bilateral tarsal disorganisation which can develop in Hansen's disease is usually not recognised by the clinician.

Purification of an allergenic protein fraction from wheat grain.

An allergenic protein fraction was isolated from wheat gluten by ion exchange and gel filtration chromatography. On sodium dodecyl sulphate gel electrophoresis the molecular mass of the protein was found to be 65 kDa. By Western blotting it was confirmed that the 65 kDa protein was the major allergenic fraction causing dermatitis herpetiformis (DH) and it contained glutamic acid and proline as the major amino acids.

Werner's Syndrome.

A 41-year old unmarried man presented with erosions, ulcers and keratosis of tendoachilles. He was short statured and had features of premature aging, sclerosis of the skin of the limbs and hypogonadism. The head was small with a beak-like nose.