Phenotypic, trophic, and regenerative properties of mesenchymal stem cells from different osseous tissues.

Mesenchymal stem cells (MSCs) have broad-based therapeutic potential in regenerative medicine. However, a major barrier to their clinical utility is that MSCs from different tissues are highly variable in their regenerative properties. In this study, we defined the molecular and phenotypic identities of different MSC populations from different osseous tissue sites of different patients and, additionally, determined their respective regenerative properties.

Home Invasion Homicide Offenders: An Analysis of Subsequent Prison Rule Violations.

This study adds to the small body of research on home invasion by describing the circumstances surrounding home invasions that resulted in the death of a resident. The 2 most common types of home invasion homicides (HIHs) involved "drug ripoffs" and robberies of older adults for money and property. The study also examined subsequent rule-violating behavior of 132 HIH inmates while incarcerated.

Assaults on Inmates and Staff by Perpetrators of Intimate Partner Homicide: An Examination of Competing Hypotheses.

The current study presents the results of an analysis of serious and assaultive prison rule violating behavior among male perpetrators of intimate partner homicide (IPH). Data on prison rule violations were collected from a sample of 189 inmates convicted of IPH in a large, southern prison system. The study focused on the degree of continuity in violent behavior among IPH offenders from the community to the prison setting.

Dual-phase osteogenic and vasculogenic engineered tissue for bone formation.

Minimally invasive, injectable bone tissue engineering therapies offer the potential to facilitate orthopedic repair procedures, including in indications where enhanced bone regeneration is needed for complete healing. In this study, we developed a dual-phase tissue construct consisting of osteogenic (Osteo) and vasculogenic (Vasculo) components. A modular tissue engineering approach was used to create collagen/fibrin/hydroxyapatite (COL/FIB/HA) hydrogel microbeads containing embedded human bone marrow-derived mesenchymal stem cells (bmMSC).

Protease-sensitive PEG hydrogels regulate vascularization in vitro and in vivo.

Forming functional blood vessel networks in engineered or ischemic tissues is a significant scientific and clinical hurdle. Poly(ethylene glycol) (PEG)-based hydrogels are adapted to investigate the role of mechanical properties and proteolytic susceptibility on vascularization. Four arm PEG vinyl sulfone is polymerized by Michael-type addition with cysteine groups on a slowly degraded matrix metalloprotease (MMP) susceptible peptide, GPQG↓IWGQ, or a more rapidly cleaved peptide, VPMS↓MRGG.