Publications by authors named "M Vidal Denis"
Article Synopsis
- - A novel method for creating substituted pyridines from iodoenones is introduced, using a two-step process that includes Sonogashira coupling with a free alkyne.
- - The process involves a sequence of chemical reactions, including thiophenol treatment and a Michael-retro-Michael process, leading to the final pyridine structure.
- - This technique allows for the incorporation of various substituents at different positions on the pyridine ring, expanding possibilities for synthesizing bioactive heterocycles.
Article Synopsis
- HSCT is a potentially curative treatment for blood and immune diseases but often involves harmful chemotherapy or radiation, leading to serious side effects like infections and secondary cancers.
- Research has shown that using targeted monoclonal antibodies (mAbs) against αCD117 can offer a safer alternative for HSCT preparations, with promising results in SCID mouse models.
- The study identifies that the ACK2 mAb effectively inhibits HSC proliferation and enhances engraftment after HSCT, and when combined with the αCD47 mAb, it significantly improves outcomes in wildtype mouse models.
Raw milk is considered a high-risk source of Campylobacter due to faecal contamination from healthy cattle and farm environments, thus linking raw milk consumption to global outbreaks. Detection of Campylobacter in raw milk poses challenges due to low contamination levels and antibacterial properties of the milk. Culture-based protocols for Campylobacter detection in milk vary, mainly with regard to pH adjustment and the choice of enrichment broth.
View Article and Find Full Text PDFmiRNAs constitute fine-tuners of gene expression and are implicated in a variety of diseases spanning from inflammation to cancer. miRNA expression is deregulated in rheumatoid arthritis (RA); however, their specific role in key arthritogenic cells such as the synovial fibroblast (SF) remains elusive. Previous studies have shown that expression is upregulated in RA SFs.
View Article and Find Full Text PDFArticle Synopsis
- Acute and chronic anal fissures are common health issues that lead to significant discomfort and frequent doctor visits; therefore, evidence-based treatment guidelines are crucial.
- A Delphi consensus method was used to review existing literature and create a set of statements regarding the treatment options for anal fissures, finalized by January 2023.
- The guidelines emphasize that both men and women are equally affected, conservative treatments should be tried first, and surgical options like lateral internal sphincterotomy and fissurectomy can be considered if conservative methods fail.