Investigation of Copy Number Variation in South African Patients With Congenital Heart Defects.

Background: Congenital heart disease (CHD) is a leading non-infectious cause of pediatric morbidity and mortality worldwide. Although the etiology of CHD is poorly understood, genetic factors including copy number variants (CNVs) contribute to the risk of CHD in individuals of European ancestry. The presence of rare CNVs in African CHD populations is unknown.

Profile and management of acute coronary syndromes at primary- and secondary-level healthcare facilities in Cape Town.

Background: Little is known about the clinical profile and management of patients with acute coronary syndromes (ACS) in the South African public sector.

Methods: We conducted a retrospective study of patients presenting with ACS to a secondary-level healthcare facility in Cape Town during a one-year period to study the clinical profile and management of these patients.

Results: Among the 214 patients in this cohort, 48 (27.