Publications by authors named "M Vernier"
Objective: The objective of this case series is to describe the indications, methodology, and short-term outcomes of three cats with severe azotemia managed with pleural dialysis.
Case Summary: Three cats were presented separately to the emergency room (ER) on referral for severe azotemia of varying etiologies. Despite aggressive medical and/or surgical management, none of the cats showed improvement in their blood urea nitrogen (BUN) or creatinine values.
Article Synopsis
- The ELN gene produces tropoelastin, crucial for forming elastic fibers that maintain tissue elasticity, and its decline is associated with aging and age-related diseases.
- Decreased ELN levels in human and mouse fibroblasts lead to premature cellular senescence, but this process is linked to increased HMOX1 rather than direct elastic fiber degradation.
- The study identifies a novel pathway where the decrease in ELN activates HMOX1 through transcription factors p53 and NRF2, resulting in iron accumulation and alterations in gene expression that promote senescence.
Article Synopsis
- Cellular senescence is a process where cells stop dividing due to stress, leading to inflammation and age-related diseases, while contributing to lifespan regulation.
- Recent research indicates that metabolic changes linked to senescence are not completely understood, especially the role of the mevalonate pathway, which produces cholesterol and other important molecules.
- This study shows that the mevalonate pathway enhances senescence in human cells by affecting cholesterol, which disrupts mitochondria and increases oxidative stress, linking cholesterol levels to age-related cellular dysfunction.
This paper presents the Synthetic Polyphonic Ambient Sound Source (SPASS) dataset, a publicly available synthetic polyphonic audio dataset. SPASS was designed to train deep neural networks effectively for polyphonic sound event detection (PSED) in urban soundscapes. SPASS contains synthetic recordings from five virtual environments: park, square, street, market, and waterfront.
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