[Epidemic of penicillinase-producing, tetracycline-resistant gonococci; risk factors for their spread].

Objective: To assess whether the 1989 epidemic of tetracycline-resistant (TRNG) and penicillinase-producing Neisseria gonorrhoeae (PPNG) was caused by a small number of imported strains, and what the risk factors for infection were.

Design: Retrospective.

Setting: The National Institute of Public Health and Environmental Protection (NIPHEP).

Surveillance of the antibiotic susceptibility of non-penicillinase producing Neisseria gonorrhoeae in The Netherlands from 1983 to 1986.

From 1983 to 1986 more than 2000 non-penicillinase producing Neisseria gonorrhoeae from Amsterdam, The Hague and Rotterdam were auxotyped and screened for susceptibility to 10 antibiotics by MIC determination. By far the commonest auxotypes were N.R.

[Quantitative study of the sensitivity of Bordetella bronchiseptica and Pasteurella multocida to sulfonamides].

Information concerning the resistance to sulfonamides in the Netherlands was obtained by determining the minimal inhibitory concentrations (MIC's) of 119 strains of Bordetella bronchiseptica and 151 strains of Pasteurella multocida, obtained from pigs at five veterinary bacteriology centres, to sulfadimidine (SDM) and sulfamethoxazole (SMX). The MIC's of SDM against Su-susceptible strains were usually 4 times higher than those of SMX. About one third of B.

Relationship between auxotype, plasmid pattern and susceptibility to antibiotics in penicillinase-producing Neisseria gonorrhoeae.

The relationship between auxotype, plasmid pattern and susceptibility to antibiotics has been studied in 2396 penicillinase-producing Neisseria gonorrhoeae isolated in The Netherlands during 1982 and 1983. The most prevalent auxotypes were proline requiring (Pro-; 44%) and non-requiring with inhibition by phenylalanine (NR Pheni; 39%). The majority (97%) of the Pro- strains carried the 4.