Publications by authors named "M Ventriglia"
Introduction: The contribution of Cannabinoid type 1 receptor (CB1) in mitochondrial energy transduction mechanisms and mitochondrial activities awaits deeper investigations. Our study aims to assess the impact of CB1 absence on the mitochondrial compartment in the liver, focusing on both functional aspects and remodeling processes.
Methods: We used CB1 and CB1 male mice.
Introduction: The wearing-off phenomenon is characterized by the recurrence of motor and non-motor symptoms of Parkinsonism during a period free from levodopa. It is a pivotal aspect marking the end of the pharmacological "honeymoon" period in Parkinson's disease (PD). A growing body of literature is connecting sex with the likelihood of developing fluctuations.
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- - The study investigates how cannabinoid type 1 receptor (CB1) signaling affects the gastrocnemius muscle, particularly its role in maintaining mitochondrial balance and function.
- - Observations indicate that mice lacking CB1 show changes in muscle fiber composition, with more oxidative fibers and improved oxidative capacity, yet this comes with increased oxidative stress and weakened antioxidant defenses.
- - Findings suggest that CB1 influences not only mitochondrial production and dynamics but also protein quality control, revealing complex interactions that enhance our understanding of muscle physiology and cellular adaptability to CB1 signaling.
Background: Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide and a public health problem. Several clinical studies have shown that copper (Cu) is involved in carcinogenesis, possibly via cuproptosis, a new form of programmed cell death, but the conclusions from published reports are inconsistent. This study aimed at evaluating the potential of Cu dysregulation as a CRC susceptibility factor.
View Article and Find Full Text PDFIntroduction: Treatment-free remission (TFR) in patients with chronic myeloid leukemia in chronic phase is considered a safe option if suitable molecular monitoring is available. However, the question arises as to which factors can contribute to the maintenance of TFR, and immunologic surveillance of the remaining leukemic cells is believed to be one of them. Argentina Stop Trial is an open-label, single-arm, multicenter trial assessing TFR after tyrosine kinase inhibitors interruption, that after more than 4 years showed a successful TFR rate of 63%.
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