Publications by authors named "M Venkatachalam"
Article Synopsis
- The study aimed to investigate hip range of motion (ROM) and hamstring flexibility in individuals with chronic nonspecific low back pain (CNLBP) compared to healthy controls, revealing potential issues with hip joint mobility.
- Results showed that those with CNLBP had significant decreases in hip adduction and internal rotation, while displaying increased hip flexion, extension, abduction, and external rotation, suggesting they exhibit a hip capsular pattern.
- However, there was no significant difference in hamstring flexibility between the CNLBP group and the control group, indicating that hamstring tightness is not associated with CNLBP.
BACKGROUNDIn type 1 diabetes (T1D), impaired insulin sensitivity may contribute to the development of diabetic kidney disease (DKD) through alterations in kidney oxidative metabolism.METHODSYoung adults with T1D (n = 30) and healthy controls (HCs) (n = 20) underwent hyperinsulinemic-euglycemic clamp studies, MRI, 11C-acetate PET, kidney biopsies, single-cell RNA-Seq, and spatial metabolomics to assess this relationship.RESULTSParticipants with T1D had significantly higher glomerular basement membrane (GBM) thickness compared with HCs.
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- Diabetic kidney disease (DKD) can cause serious health issues, including end-stage kidney disease (ESKD) and even death, but we don't have many tests to find out who is at high risk, especially if they don't have noticeable problems.
- Researchers studied the urine of people with diabetes to see if a special test called urine adenine/creatinine ratio (UAdCR) could help identify those at risk for ESKD.
- They found that higher levels of UAdCR were linked to higher chances of ESKD and that a medicine named empagliflozin could lower these levels, suggesting that adenine in the body might be a key player in causing kidney problems for people with diabetes.
Article Synopsis
- Diabetic kidney disease (DKD) can get really serious and lead to end-stage kidney disease (ESKD), but it's hard to find tests for high-risk patients who don't show clear signs.
- Scientists studied urine from diabetes patients to see if the amount of a substance called adenine in urine could help predict ESKD risks.
- They found that high levels of adenine in urine were linked to more kidney problems, and a medicine reduced those levels, suggesting that adenine could be causing some kidney damage in diabetes.