Targeting the TDP-43 low complexity domain blocks spreading of pathology in a mouse model of ALS/FTD.

Abnormal cytoplasmic localization and accumulation of pathological transactive response DNA binding protein of 43 kDa (TDP-43) underlies several devastating diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP). A key element is the correlation between disease progression and spatio-temporal propagation of TDP-43-mediated pathology in the central nervous system. Several lines of evidence support the concept of templated aggregation and cell to cell spreading of pathological TDP-43.

Targeting amyotrophic lateral sclerosis by neutralizing seeding-competent TDP-43 in CSF.

In amyotrophic lateral sclerosis, a disease driven by abnormal transactive response DNA-binding protein of 43 kDa aggregation, CSF may contain pathological species of transactive response DNA-binding protein of 43 kDa contributing to the propagation of pathology and neuronal toxicity. These species, released in part by degenerating neurons, would act as a template for the aggregation of physiological protein contributing to the spread of pathology in the brain and spinal cord. In this study, a robust seed amplification assay was established to assess the presence of seeding-competent transactive response DNA-binding protein of 43 kDa species in CSF of apparently sporadic amyotrophic lateral sclerosis patients.

Measurements of Volatile Organic Compounds at a rural site in India: Variability and sources during the seasonal transition.

Volatile Organic Compounds (VOCs) play a vital role in tropospheric ozone formation that controls the oxidative capacity of the troposphere. A total of 31 potential ozone precursor VOCs have been measured at a tropical rural site, Gadanki (13.5°N, 79.

Changing patterns in the highly contributing aerosol types/species across the globe in the past two decades.

With the rapidly changing aerosol emissions due to the increase in urbanization, energy consumption, population density, and industrialization in the past two decades across the globe, there is an evolution of different chemical properties of aerosols that are yet not quantified properly. Therefore, a rigorous attempt is made in this study to obtain the long-term changing patterns in the contribution of different aerosol types/species, to the total aerosol loading. This study is carried out only over those regions exhibiting either increasing or decreasing trends in the aerosol optical depth (AOD) parameter on a global scale.