Understanding Polysulfide-Mediated Papain Inhibition and Differentiating between Disulfide vs Persulfide Formation.

Protein cysteine residues are sensitive to redox-regulating molecules, including reactive sulfur species (RSS). As an important member of the RSS family, polysulfides are known to react with protein cysteines to form persulfides and disulfides, both affecting protein functions. In this work, we studied how polysulfides could impact cysteine proteases through careful mechanistic and kinetic studies.

Flexible and configurable embedded electrical energy measurement system to acquire and process high-frequency features.

A novel High-Frequency Electric Energy Metering System to inspect non-conventional features that may be relevant for studying real-time energy disaggregation and control of household appliances is presented. Integration of a data acquisition and control board, designed and built to be assembled with an Arduino Due, with the M90E36A Demo Board, allows for flexible and configurable electrical energy measurements. A key feature is that up to 4 current channels can be measured synchronously.

Active alcohol consumption is associated with acute-on-chronic liver failure in Hispanic patients.

Background: Acute-on-chronic liver failure (ACLF) is a severe clinical entity associated with elevated short-term mortality. We aimed to characterize patients with decompensated cirrhosis according to presence of ACLF, their association with active alcohol intake, and long-term survival in Latin America.

Methods: Retrospective cohort study of decompensated cirrhotic in three Chilean university centers (2017-2019).

The effectiveness of a tablet-based video game that stimulates cognitive, emotional, and social skills in developing academic skills among preschoolers: study protocol for a randomized controlled trial.

Background: Evidence suggests that children from low-income families begin the preschool stage with less academic and non-academic skills development compared to higher-income families. There are several successful experiences of early stimulation of cognitive and social-emotional skills; however, there is scarce evidence of the effectiveness of a video game that incorporates the stimulation of these skills simultaneously. This study aims to evaluate the effectiveness of a video game in stimulating cognitive, emotional, and social competence skills in developing academic skills in socioeconomically disadvantaged preschool children.

Wind-Driven Sediment Resuspension in the World's Fourth Largest Lake Contributes Substantial Phosphorus Load to the 11th Largest Lake.

Capturing precipitation-based episodes is a longstanding issue for estimating tributary loads; however, wind-driven resuspension in Lake Huron creates similar uncertainties in its estimated load to Lake Erie. Recent suggestions that the phosphorus load from Lake Huron is underestimated because sampling frequencies miss contributions from resuspension events are speculative because they did not include direct load measurements, address all resuspension regions, or assess the potential bioavailability of the load. We address these shortcomings by evaluating Lake Huron's nearshore regions, characterizing the biological availability of the load, and providing direct comparisons of load estimates with and without the resuspended load.