Publications by authors named "M Velasquez-Lopera"
Introduction: Atopic dermatitis (AD) is a frequent disease in infants with diverse clinical evolution. Although multiple studies have assessed inflammatory changes in chronic AD, little is known about the molecular transition from symptomatic stage to clinical remission without pharmacotherapy.
Objective: The aim of the study was to evaluate clinical and inflammatory factors and its relationship with AD clinical evolution.
Article Synopsis
- Some babies with a specific mutation in the IL7R gene have a serious immune problem called SCID, where they lack a certain type of immune cells called T cells, but still have normal B and NK cells.
- In a study of 6 adults who have a similar genetic issue, they showed low levels of T cells but had relatively normal levels of other immune cells, indicating a more specific problem in T cell development.
- Even though their T cells didn’t grow well in the lab, the study hints that there might be another way T cells can develop that doesn’t depend solely on the IL-7 cytokine.
Severe defects in human IFNγ immunity predispose individuals to both Bacillus Calmette-Guérin disease and tuberculosis, whereas milder defects predispose only to tuberculosis. Here we report two adults with recurrent pulmonary tuberculosis who are homozygous for a private loss-of-function TNF variant. Neither has any other clinical phenotype and both mount normal clinical and biological inflammatory responses.
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- Tattoos have a long history, but complications can arise from different pigments and application methods; these reactions can be categorized into inflammatory, infectious, neoplastic, aesthetic, and miscellaneous types.
- Histopathological studies of inflammatory reactions show various patterns, such as lichenoid or granulomatous changes.
- A significant number of tattooed individuals (up to 67%) report adverse reactions, with certain pigments, especially red ink, being common culprits; pre-existing skin conditions may worsen with tattoos, highlighting the importance of a dermatological consult before getting inked.
Vitiligo is a chronic pigmentary condition and severely impacts patient quality of life (QoL). It is an underrecognized burden for patients, healthcare systems, and society in Latin America (LA). This paper examines the journey of a vitiligo patient in LA and assesses the disease landscape.
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