Inflammatory responses in SARS-CoV-2 associated Multisystem Inflammatory Syndrome and Kawasaki Disease in children: An observational study.

Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe inflammatory disease in children related to SARS-CoV-2 with multisystem involvement including marked cardiac dysfunction and clinical symptoms that can resemble Kawasaki Disease (KD). We hypothesized that MIS-C and KD might have commonalities as well as unique inflammatory responses and studied these responses in both diseases. In total, fourteen children with MIS-C (n=8) and KD (n=6) were included in the period of March-June 2020.

[A woman with balls in the lower abdomen].

A 34-year old woman visited the general practitioner because of nausea and diarrhoea. A large abdominal swelling was palpable. Ultrasound showed a cyst containing 'floating balls', pathognomic for a mature teratoma.

Kawasaki Disease and Systemic Juvenile Idiopathic Arthritis - Two Ends of the Same Spectrum.

Kawasaki disease (KD) and systemic juvenile idiopathic arthritis (sJIA) are two distinct systemic inflammatory diseases of childhood. Each diagnosis is based on criteria, but numerous clinical features are overlapping. As no specific diagnostic tests are available, differentiation between both disease entities can be challenging.

Dissipation and dynamics in ultrafast intersystem crossings.

The effects of dynamics and dissipation on ultrafast intersystem crossings are studied for a dissipative two-level system coupled to a local vibronic mode. A method of amplitude damping of the wave packet is presented that accounts better for the position of the wave packet and avoids spurious transitions between potential wells. It is demonstrated that Fermi's golden rule, the typical semiquantitative approach to extract population transfer rates from potential landscapes, only holds under limited conditions.

Age- and sex-specific prevalence of chronic comorbidity in adult patients with asthma: A real-life study.

The presence of comorbidity can be associated with poorer asthma outcomes. Previous prevalence studies focused on a limited selection of comorbid conditions in asthma only. We aimed to determine age- and sex-specific prevalence estimates for the full range of chronic comorbid conditions in adult asthma patients by performing a retrospective cohort study based on 32,787 medical records of patients aged ≥16 years with asthma from 179 general practices in the Netherlands.