Publications by authors named "M Vater"
Purpose: While MEK inhibitors demonstrated activity in metastatic triple negative breast cancer (mTNBC) preclinical studies, preclinical, and clinical studies implicate rapid development of resistance limiting clinical benefit. The purpose of this study was to determine response rate for Trametinib alone and in combination with Uprosertib in patients with mTNBC previously treated with chemotherapy.
Methods: This was an open-label, two-part, phase II, single-arm, multicenter study.
Article Synopsis
- Huntington's disease (HD) is linked to psychiatric symptoms, but the effects of variations in the huntingtin gene (HTT) CAG repeat sizes on psychiatric disorders like major depressive disorder (MDD) and anxiety disorders (ANX) are not well-studied.
- In this study, researchers compared CAG repeat sizes among patients with MDD and ANX to healthy controls, finding that certain repeat ranges did not show an overrepresentation among patients and that age influenced the associations between repeat sizes and psychiatric risks.
- The findings suggest that variations in CAG repeat sizes in the non-HD range can modulate the risk for psychiatric disorders and affect basal ganglia structure, highlighting the potential impact of the normal huntingtin protein
Article Synopsis
- The study investigates how stromal tumor-infiltrating lymphocytes (sTILs) relate to survival in patients with metastatic breast cancer (MBC).
- The research showed that sTILs positively impacted progression-free survival in those receiving chemotherapy, but this link weakened after accounting for hormone receptor status.
- The trial involved is CALGB 40502, which has since become part of the Alliance for Clinical Trials in Oncology and is registered on ClinicalTrials.gov.
Objective: Little is known about health literacy in childhood-onset systemic lupus erythematosus (cSLE) and how health literacy relates to medication adherence and psychosocial outcomes in this high-risk population. The objective of this study was to evaluate health literacy in adolescents and young adults with cSLE and its association with medication adherence and quality of life.
Methods: Youth 10-24 years with cSLE ( = 48) completed the Brief Healthy Literacy Screen (BHLS) and the Newest Vital Sign (NVS) to assess health literacy.
Background And Objectives: A clinical practice guideline (CPG) was created to standardize evaluation and treatment for patients with suspected anti-methyl-d-aspartate receptor (NMDAR) autoimmune encephalitis (AE), the most common AE in children. The objective of this study was to evaluate the CPG effect on time to diagnosis, treatment, and hospital length of stay (LOS).
Methods: Patients with an inpatient consult to pediatric rheumatology for AE during a 4-year period (period 2) after CPG implementation were identified.