Isolation of anaerobic organisms from kidney in serious renal infections.

We have studied 45 patients who underwent nephrectomy owing to unilateral renal sepsis for anaerobic and aerobic bacterial growth in the urine and kidney. Anaerobic organisms were recovered from 11 patients: 10 had positive kidney cultures, and only 1 had positive kidney and urine cultures. There was a distinct relationship between anaerobic infection of the kidney and urinary tract obstruction; 44 per cent of the obstructed kidneys yielded anaerobic organisms versus only 11 per cent of the unobstructed kidneys.

Kidney damage in recurrent renal lithiasis. A survey of 175 cases with clinicopathological observations.

We evaluated the degree of kidney damage in 175 patients treated by nephrectomy for recurrent renal stones. Renal histopathological lesions of the removed kidneys were graded and correlated to clinical and operative findings. Nonexcreting kidneys on intravenous pyelography or small atrophic kidneys with poor contrast excretion showing advanced hydronephrosis and pyelonephritic scarring intraoperatively corresponding to kidneys with advanced parenchymatous destruction histopathologically.

The response of the juxtaglomerular apparatus to stimuli effecting renin or erythropoietin release in canine renal allografts.

The functioning canine renal allograft produces plasma renin activity (PRA) and erythropoietin (ESF) activity and can maintain normal blood pressure and normal erythropoiesis. Moreover, in response to various provocative stimuli it can: (i) increase plasma renin activity in response to low sodium intake; (ii) suppress PRA in response to high sodium intake; (iii) produce increased serum erythropoietin in response to hypoxia. The granulation activity of the juxtaglomerular apparatus correlates best with the degree of graft rejection and with the PRA in groups manipulated by changing sodium balance.