Publications by authors named "M Vanessa Perez-Gomez"
Measured and Estimated Glomerular Filtration Rate to Evaluate Rapid Progression and Changes over Time in Autosomal Polycystic Kidney Disease: Potential Impact on Therapeutic Decision-Making.
Int J Mol Sci
May 2024
Article Synopsis
- Autosomal polycystic kidney disease (ADPKD) is a genetic condition leading to kidney failure, with tolvaptan being the only approved treatment, but it's only for those with rapid disease progression.
- A study assessed the accuracy of estimating GFR decline through serum creatinine and cystatin-C formulas, noting poor agreement with actual measured GFR declines using iohexol clearance.
- This discrepancy means that about 37% of rapid GFR declines were missed, and many stable cases were wrongly identified as rapid progressors, which could lead to incorrect treatment decisions for tolvaptan therapy.
Background: Chronic kidney disease (CKD), especially diabetic CKD, is the condition that most increases the risk of lethal coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the underlying molecular mechanisms are unclear. SARS-CoV-2 and coronavirus-associated receptors and factors (SCARFs) regulate coronavirus cell entry and/or replication.
View Article and Find Full Text PDFAim: To study the health status of a group of patients with liver transplantation by alcohol-related disease vs another etiology before and after the transplantation.
Method: Longitudinal cohort study of liver transplant patients from November 2019 to July 2022. Adult patients attended in the unit of transplantation of a hospital for a first liver transplant, both elective and urgent, were included.
Article Synopsis
- The study focuses on the clinical features of autosomal dominant polycystic kidney disease (ADPKD) in young adults aged 18-30, highlighting their morbidity despite the disease typically appearing in adulthood.
- In a cohort of 346 young adults, the average age of hypertension diagnosis was just over 21, with a prevalence of 28%, which increased with age.
- The findings suggest that young adults with ADPKD experience significant health issues, underscoring the importance of early detection and management of hypertension in this group.