Publications by authors named "M Vandromme"
Phosphoinositides also called Polyphosphoinositides (PPIns) are small lipid messengers with established key roles in organelle trafficking and cell signaling in response to physiological and environmental inputs. Besides their well-described functions in the cytoplasm, accumulating evidences pointed to PPIns involvement in transcription and chromatin regulation. Through the description of previous and recent advances of PPIns implication in transcription, this review highlights key discoveries on how PPIns modulate nuclear factors activity and might impact chromatin to modify gene expression.
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- * A study analyzed electronic health records from over 21,000 patients to see if heparin therapy led to a delay in AD dementia diagnosis, factoring in various patient characteristics.
- * Results showed that heparin therapy was linked to a significant delay in the clinical diagnosis of AD dementia by approximately 1 year in both health system cohorts, suggesting potential protective effects of heparin-like drugs against AD.
BackgroundThe Belgian COVID-19 vaccination campaign aimed to reduce disease spread and severity.AimWe estimated SARS-CoV-2 variant-specific vaccine effectiveness against symptomatic infection (VEi) and hospitalisation (VEh), given time since vaccination and prior infection.MethodsNationwide healthcare records from July 2021 to May 2022 on testing and vaccination were combined with a clinical hospital survey.
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- This study examined how effective vaccines are in preventing severe COVID-19 outcomes, like ARDS, ICU admission, and death, among hospitalized patients in Belgium during a Delta variant surge.
- Researchers analyzed data from 2,493 patients and found that those who were fully vaccinated had significantly lower chances of severe disease and in-hospital death compared to those unvaccinated.
- Different vaccine types were compared, showing that mRNA vaccines and the AstraZeneca vaccine provided similar protection for older patients, while a single dose of the Johnson & Johnson vaccine had lower effectiveness in this age group.
Predicting COVID-19 progression in hospitalized patients in Belgium from a multi-state model.
Front Med (Lausanne)
November 2022
Objectives: To adopt a multi-state risk prediction model for critical disease/mortality outcomes among hospitalised COVID-19 patients using nationwide COVID-19 hospital surveillance data in Belgium.
Materials And Methods: Information on 44,659 COVID-19 patients hospitalised between March 2020 and June 2021 with complete data on disease outcomes and candidate predictors was used to adopt a multi-state, multivariate Cox model to predict patients' probability of recovery, critical [transfer to intensive care units (ICU)] or fatal outcomes during hospital stay.
Results: Median length of hospital stay was 9 days (interquartile range: 5-14).