The Efficacy of Botulinum Toxin A Injection in Pelvic Floor Muscles in Chronic Pelvic Pain Patients: A Double-Blinded Randomised Controlled Trial.

Objective: To evaluate and compare the efficacy and safety of Botulinum Toxin A (BTA) injections versus placebo injections, combined with pelvic floor muscle therapy (PFMT), in women with chronic pelvic pain (CPP).

Design: Randomised, double-blinded clinical trial (January 2020-April 2023).

Setting: This multicentre study was conducted at four hospitals in the Netherlands.

Charging and Mobilization of Dust Particles on a Surface in Plasma.

We present first experimental results showing that single dust particles on a dielectric surface are mobilized and lofted due to exposure to an electron beam or ultraviolet radiation. It is shown that secondary electrons and/or photoelectrons emitted from a substrate surface are recollected on the surfaces within microcavities between a dust particle and the substrate surface, resulting in large negative charges and subsequently causing mobilization of the dust particle due to Coulomb repulsion. Dust mobility tested against the electron beam energy is shown to follow the secondary electron yield curve of the substrate surface in both the experimental and modeling results.

Blood-Brain Barrier Integrity Decreases With Higher Blood Pressure: A 7T DCE-MRI Study.

Background: Blood-brain barrier (BBB) integrity is presumed to be impaired in hypertension, resulting from cerebral endothelial dysfunction. Hypertension precedes various cerebrovascular diseases, such as cerebral small vessel disease, and is a risk factor for developing neurodegenerative diseases for which BBB disruption is a preceding pathophysiological process. In this cross-sectional study, we investigated the relation between hypertension, current blood pressure, and BBB leakage in human subjects.

Lead Optimization of the 5-Phenylpyrazolopyrimidinone NPD-2975 toward Compounds with Improved Antitrypanosomal Efficacy.

Human African trypanosomiasis (HAT) still faces few therapeutic options and emerging drug resistance, stressing an urgency for novel antitrypanosomal drug discovery. Here, we describe lead optimization efforts aiming at improving antitrypanosomal efficacy and better physicochemical properties based on our previously reported optimized hit NPD-2975 (pIC 7.2).