Social Influence in Social-Ecological Systems: Collaborative Capacity and Inter-Organizational Networks in the U.S. Sagebrush.

Collaborative governance has become a prominent, if not dominant, framework for thinking about multi-scalar and cross-jurisdictional environmental management. The literature broadly and consistently suggests that collaborative capacity and inter-organizational networks provide the institutional framework for addressing social-ecological system challenges. Surprisingly little scholarship addresses processes of social influence (or contagion) in social-ecological systems writ large, or more specifically as it relates to collaborative capacity.

Dosimetric implications of kidney anatomical volume changes in Lu-DOTATATE therapy.

Introduction: This study aims to evaluate the use of CT-based whole kidney parenchyma (WKP) segmentation in Lu-DOTATATE dosimetry. Specifically, it investigates whether WKP volumes change during treatment and evaluates the accuracy of applying a single delineated WKP volume for dosimetry. Furthermore, it aims to determine the cause of WKP volume changes-whether caused by radiation or amino acid infusion-by comparing them with spleen volume changes as a marker for radiation-induced alterations.

PTCH1-mutant human cerebellar organoids exhibit altered neural development and recapitulate early medulloblastoma tumorigenesis.

Patched 1 (PTCH1) is the primary receptor for the sonic hedgehog (SHH) ligand and negatively regulates SHH signalling, an essential pathway in human embryogenesis. Loss-of-function mutations in PTCH1 are associated with altered neuronal development and the malignant brain tumour medulloblastoma. As a result of differences between murine and human development, molecular and cellular perturbations that arise from human PTCH1 mutations remain poorly understood.

Fibroblast Activation Protein-Targeting Minibody-IRDye700DX for Ablation of the Cancer-Associated Fibroblast with Photodynamic Therapy.

Fibroblast activation protein (FAP), expressed on cancer-associated fibroblasts, is a target for diagnosis and therapy in multiple tumour types. Strategies to systemically deplete FAP-expressing cells show efficacy; however, these induce toxicities, as FAP-expressing cells are found in normal tissues. FAP-targeted photodynamic therapy offers a solution, as it acts only locally and upon activation.