Publications by authors named "M Van As"
Emerging Biomarkers for Assessing Thrombotic Risk in Patients Receiving Direct Oral Anticoagulants (DOACs).
Cardiovasc Hematol Agents Med Chem
December 2024
Direct Oral Anticoagulants (DOACs) have transformed the management of thrombotic disorders, offering a more convenient and effective alternative to traditional vitamin K antagonists (VKAs). However, assessing thrombotic risk in patients treated with DOACS remains crucial due to the potential for recurrent events. Current clinical risk scores have limitations in predicting and monitoring venous thromboembolism (VTE) risk in specific DOAC populations.
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- CRISPR-Cas9 gene editing offers potential treatments for retinal dystrophies by targeting specific genes in retinal cells.
- Unlike viral delivery methods that can cause long-term effects, this study focuses on transient delivery of Cas9 protein and guide RNA as ribonucleoprotein complexes.
- The research shows these complexes can enter retinal cells directly, but higher concentrations can be toxic, highlighting the need for enhanced delivery techniques for safe and effective therapies.
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- Industrial activities, especially leather industries, are very important for India's economy because they create jobs and generate money.
- However, these industries also cause a lot of pollution, mainly from harmful chemicals like hexavalent chromium, which can be very dangerous for people, animals, and plants.
- The text talks about ways to clean up this pollution using special plants that can absorb the toxins, and it suggests that more research is needed to find better ways to manage the waste from tanneries.
Tardigrades are microscopic animals renowned for their ability to withstand extreme conditions, including high doses of ionizing radiation (IR). To better understand their radio-resistance, we first characterized induction and repair of DNA double- and single-strand breaks after exposure to IR in the model species . Importantly, we found that the rate of single-strand breaks induced was roughly equivalent to that in human cells, suggesting that DNA repair plays a predominant role in tardigrades' radio-resistance.
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