Partial genome analysis of murine gammaherpesvirus 4556.

Unlabelled: Murine gammaherpesvirus 68 (MHV-68) -infected mouse is an animal model of gammaherpesvirus infection in man and domestic animals. Murine gammaherpesvirus 4556 (MHV-4556), isolated from Apodemus flavicollis ticks has been considered a close relative of MHV-68 but different in some features of infection in vitro and in vivo. Previous comparison of MHV-4556 with MHV-68 has revealed their diversity in immune evasion protein MK3.

Partial genome sequence of murine gammaherpesvirus 72 and its analysis.

Murine gammaherpesvirus 68 (MHV-68)-infected mouse is a well known model for studies of Epstein-Barr virus (EBV)-related lymphoproliferative diseases (LPD). Murine gammaherpesvirus 72 (MHV-72) has been considered a close relative of MHV-68 but its replication in murine mammary gland cells and kinetics of infection of mice were found to be different. Pathological studies of a long-term-infection of mice revealed a similar or higher malignancy development rate in MHV-72-infected mice as compared with that of MHV-68.

Occurrence of human papillomavirus 16 and 18 in smears from the two cervix regions of onco-gynecological patients in Slovakia.

We evaluated the relevance of tests for Human papillomavirus 16 and 18 (HPV-16, HPV-18) in two cervix regions (exocervical and endocervical) separately. The total of 142 cervical smears obtained from 91 women in Slovakia attending onco-gynecological outpatient care were examined for the presence of HPVs by PCR with the general primers GP5 and GP6 (GP5/6). The HPV-positive smears were examined for the presence of HPV-16 and HPV-18 and the results compared with cytological assessment.

Murine gammaherpesvirus (MHV) MK3 gene sequence diversity among 72, 4556, and 68 strains.

Murid herpesvirus 4 (MuHV-4) currently serves as a model for study of human gamma-herpesvirus pathogenesis. It codes for MK3 protein that similarly as K5 protein of Kaposi's sarcoma-associated herpesvirus are members of a family of structurally related viral immune evasion molecules possessing RING-CH finger domain with ubiquitin ligase activity. Murine herpesvirus 72 (MHV-72) isolated from the same species of free-living small rodent is considered as closely related to Murine herpesvirus 68 (MHV-68).