Publications by authors named "M Valle Enguix-Riego"
Background: Small cell lung cancer (SCLC) is one of the greatest therapeutic challenges of oncology. Potential associations between single nucleotide polymorphisms in heat shock protein β1 (HSPB1) and transforming growth factor β1 (TGFβ1) and survival have been investigated.
Methods: A prospective multicenter study of 94 patients with SCLC treated between 2013 and 2016 was conducted.
Canonical prefoldin is a protein cochaperone composed of six different subunits (PFDN1 to 6). PFDN1 overexpression promotes epithelial-mesenchymal transition (EMT) and increases the growth of xenograft lung cancer (LC) cell lines. We investigated whether this putative involvement of canonical PFDN in LC translates into the clinic.
View Article and Find Full Text PDFBackground And Purpose: Radiochemotherapy (RCT) success in lung cancer (LC) can be limited due to the onset of adverse effects in the adjacent normal tissue such as radiation-induced esophageal toxicity (RIET). Therefore, specific biomarkers to customize the RCT dose administration and esophageal toxicity prediction are necessary to improve treatment effectiveness.
Materials And Methods: 247 LC patients prospectively recruited between 2012 and 2016 from 3 institutions were genotyped for 7 SNPs along TGFB1 and HSPB1 genes seeking an association with RIET risk development.
The single nucleotide variant rs2868371 associates with the risk of mortality in non-small cell lung cancer patients: A multicenter prospective validation.
Radiother Oncol
July 2019
Background And Purpose: Definitive radiation therapy (RT) with or without chemotherapy has become the standard treatment for non-metastatic unresectable non-small cell lung cancer (NSCLC). However, treatment outcomes can differ substantially and patients' genetic background could play a crucial role. Potential associations between single-nucleotide polymorphisms (SNP) in Heat shock protein beta-1 (HSPB1) and survival have been reported in prior single-institution retrospective reports.
View Article and Find Full Text PDFArticle Synopsis
- Hirschsprung disease (HSCR) is caused by issues in the migration and development of neural crest cells in the bowel during embryonic development of the Enteric Nervous System (ENS).
- Researchers conducted a study to identify new transcription factors involved in the colonization process of ENS, comparing samples from HSCR patients and controls.
- Significant findings included lower expression levels of the transcription factor PAX6 in HSCR patients, potentially linked to genetic mutations affecting its promoter, which might lead to disruptions in ENS signaling pathways and contribute to HSCR symptoms.