Publications by authors named "M Valeanu"
Article Synopsis
- The study investigates the potential role of specific variants of human leukocyte antigens (HLA) and microRNAs (miRNAs) in determining risk for mild cognitive impairment (MCI) and Alzheimer's disease (AD).
- A systematic review and meta-analysis were performed using international databases to assess how these genetic factors contribute to cognitive decline and their potential as early biomarkers for AD.
- Results indicated that certain HLA variants are linked to increased risk for cognitive decline while others provide protection, with let-7 and miR-15/16 identified as promising miRNA biomarkers for early detection of AD.
Introduction: B-cell lymphomas with a low degree of malignancy represent a heterogeneous group of diseases, that evolve slowly, but present particularities in terms of long-term survival.
Methods: We investigated the impact of anemia from the time of diagnosis in 249 patients with malignant B-cell lymphomas, diagnosed between January 2011 and December 2015, in the Hematology Department of the Sibiu County Emergency Hospital, Romania.
Results: We included 126 (50.
: The COVID-19 era has been a bleak period for both cancer and non-cancer patients, with delayed non-emergency treatments, such as for non-melanoma skin cancer (NMSC). This study aimed to evaluate how the treatment of NMSC patients was influenced by the management of the COVID-19 pandemic in an Eastern European Maxillofacial Surgery center. : A total of 176 patients with a histopathological diagnosis of head and neck NMSC who were surgically treated in Cluj-Napoca Emergency County Hospital between 2016 and 2022 were included in this study, and divided into two samples, pre-pandemic (2016-2019) and COVID-19 (2020-2022) periods.
View Article and Find Full Text PDFStroke is a leading cause of mortality and morbidity worldwide. Treatment of this pathology is still under development and its risk factors remain to be determined. Therefore, we aim to determine the role of interleukin-1 beta in atherosclerotic lesions of the internal carotid artery as a risk factor for stroke and the role of this biomarker in stroke prognosis.
View Article and Find Full Text PDFIntroduction: Acute myeloid leukaemia (AML) is a haematological disease associated with a dismal prognosis, despite major progress made in recent years in terms of antileukemic agents and supportive care.
Methods: We investigated the results of the intensive treatment of 133 fit AML patients ( and secondary) from a referral cancer centre in Romania, treated between January 2015 and December 2021.
Results: We included 79 male and 54 female patients with a median age of 53 years (range 18-70).