Publications by authors named "M Vadori"
Antibody-mediated rejection (AMR) is the leading cause of premature kidney transplant failure. The role of alloantibodies against Human Leukocyte Antigens (HLA) has been a primary focus in AMR. More recently autoantibodies and alloantibodies against the angiotensin II receptor type 1 (AT1R) and the endothelin A receptor (ETAR) have been linked to poor allograft outcomes in kidney transplantation.
View Article and Find Full Text PDFChronic active antibody-mediated rejection is one of the leading causes of graft failure and traditional therapies have unclear efficacy. Recent studies suggested that Tocilizumab could stabilize renal function and improve microvascular inflammation. Here we report the outcomes of Tocilizumab therapy in 6 pediatric kidney transplant recipients with biopsy-proven chronic active antibody-mediated rejection resistant to standard treatments.
View Article and Find Full Text PDFCalcification of surgical aortic bioprostheses and its impact on clinical outcome.
Eur Heart J Cardiovasc Imaging
August 2024
Article Synopsis
- Aortic valve calcification (AVC) was studied in patients with bioprosthetic valves to assess its impact on patient prognosis.
- In a study of 361 patients who had valve replacements, AVC was found to be significantly higher in those with structural valve degeneration (SVD).
- The results indicate that AVC greater than 100 Agatston units is correlated with worse health outcomes and increased risk of mortality and cardiovascular events, making CT scans a valuable tool for evaluation.
Purpose Of Review: In recent years, the xenotransplantation science has advanced tremendously, with significant strides in both preclinical and clinical research. This review intends to describe the latest cutting-edge progress in knowledge and methodologies developed to overcome potential obstacles that may preclude the translation and successful application of clinical xenotransplantation.
Recent Findings: Preclinical studies have demonstrated that it is now possible to extend beyond two years survival of primate recipients of life saving xenografts.
Article Synopsis
- - The study examined the link between specific autoantibodies (AT1R-AAs and ETAR-AAs) and left ventricular remodeling (LVR) in patients who experienced a myocardial infarction (heart attack), highlighting how these antibodies affect treatment outcomes.
- - Conducted on 131 patients treated for ST-segment-elevation myocardial infarction, researchers found a significant prevalence of these autoantibodies in those who developed LVR, with 39% of patients with LVR being seropositive for AT1R-AAs.
- - The findings indicate that AT1R-AAs not only correlate with LVR but also serve as a risk factor for future serious heart-related events, suggesting potential targets for improving