Publications by authors named "M Vaadal"
Spatial transcriptomics is a technique that provides insight into gene expression profiles in tissue sections while retaining structural information. We have employed this method to study the pathological conditions related to red and melanized focal changes in farmed Atlantic salmon (Salmo salar). Our findings support a model where similar molecular mechanisms are involved in both red and melanized filet discolorations and genes associated with several relevant pathways show distinct expression patterns in both sample types.
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- - This study presents the first spatial transcriptomic atlas of Atlantic salmon skin using the Visium Spatial Gene Expression protocol, analyzing samples from four different skin areas of two fish.
- - High-quality tissue sections were created, resulting in over 80 million reads per sample and the detection of more than 80,000 transcripts and nearly 30,000 genes, with epithelial tissues showing the highest transcript counts.
- - Key findings include the identification of collagen type 1 as the most abundant gene family, along with specific gene markers for different tissue types, which were validated by a meta-analysis of existing microarray data.
Aquaporin-4 (AQP4) is a water channel found at high concentrations around blood vessels in the brain and is organized into elaborate assemblies called square arrays. The natural functions of AQP4 and the square arrays remain unknown, but under pathophysiological conditions, AQP4 has been shown to influence brain edema, synapse function, and cellular migration. AQP4 was recently found to have six isoforms, where AQP4a (also known as M1), AQP4c (also known as M23), and AQP4e are functional water transport channels.
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