A-Type Natriuretic Peptide Alters the Impact of Azithromycin on Planktonic Culture and on (Monospecies and Binary) Biofilms of Skin Bacteria and .

It has been established that the human atrial natriuretic peptide is able to alter the effect of azithromycin on H01 and 209P monospecies and binary biofilms. The effect of the hormone depends on the surface type and cultivation system, and it may have both enhancing and counteracting effects. The antagonistic effect of the hormone was observed mostly on hydrophobic surfaces, whereas the additive effect was observed on hydrophilic surfaces like glass.

C-Type Natriuretic Peptide Acts as a Microorganism-Activated Regulator of the Skin Commensals and in Dual-Species Biofilms.

The effect of C-type natriuretic peptide in a concentration closer to the normal level in human blood plasma was studied on the mono-species and dual-species biofilms of the skin commensal bacteria HL043PA2 and ATCC14990. Despite the marginal effect of the hormone on cutibacteria in mono-species biofilms, the presence of staphylococci in the community resulted in a global shift of the CNP effect, which appeared to increase the competitive properties of , its proliferation and the metabolic activity of the community. was mostly inhibited in the presence of CNP.

Epinephrine extensively changes the biofilm matrix composition in C01 isolated from human skin.

The importance of the impact of human hormones on commensal microbiota and microbial biofilms is established in lots of studies. In the present investigation, we continued and extended the research of epinephrine effects on the skin commensal C01 and its biofilms, and also the matrix changes during the biofilm growth. Epinephrine in concentration 4.

Cyclic Methacrylate Tetrahydropyrimidinones: Synthesis, Properties, (Co)Polymerization.

During radical polymerization of novel biocidal methacrylate guanidine monomers, a cyclic byproduct was discovered and identified as 2-imino-5-methyltetrahydropyrimidin-4(1H)-one (THP). Its methacrylate salt (MTHP) was synthesized and characterized via H and C NMR and pyrolysis chromatography. Synthesis conditions of both THP and MTHP were optimized to high yields, and both MTHP homopolymerization (in aqua) and copolymerization with diallyldimethylammonium chloride (in aqua in salt form) were successfully carried out with middle to high yields, providing a promising platform for potential tailored biocide polymers.

Epinephrine affects gene expression levels and has a complex effect on biofilm formation in strain C01 isolated from human skin.

In this study, the effect of epinephrine on the biofilm formation of C01 isolated from human skin was investigated in depth for the first time. This hormone has a complex effect on biofilms in various systems. In a system with polytetrafluoroethylene (PTFE) cubes, treatment with epinephrine at a physiological concentration of 4.