Proton Sponge Zwitterions with Positively and Negatively Charged Hydrogen Bonds: Extremely Polar Organic Compounds and Interplay of [NHN] and [NHN] Properties.

Six previously unknown zwitterions with positively and negatively charged [NHN] hydrogen bonds were synthesized by acylation of 4,5-bis(dimethylamino)-1-tosylamino-8-aminonaphthalene with subsequent alkaline treatment of the resulting 8-acylamino derivatives. Using NMR and XRD measurements in conjunction with quantum chemical DFT/PBE1PBE/6-311++G(d,p) calculations, it was shown that the negatively charged [NHN] bond in such compounds commonly differs from the [NHN] bond by significantly lower linearity, higher asymmetry, and moderate to strong paramagnetic shift of the chelated NH proton signal. Among other remarkable findings, the most important are (1) unusually high polarity (μ = 21-26 D) of the obtained zwitterions, (2) sharp difference in structures of the solid 1,8-bis(tosylated) zwitterion (BTZ) grown from MeCN or DMF, and (3) registration for one of the stereoisomers of BTZ with the record short [NHN] hydrogen bridge (N···N = 2.

DIABETES MELLITUS TYPE 1 IN ADOLESCENTS: IMPACT OF VITAMIN D STATUS.

Objective: The aim: To evaluate the effect of vitamin D deficiency or insufficiency on the compensation of the disease in adolescents with diabetes mellitus type 1.

Patients And Methods: Materials and methods: 124 patients were examined, among them: 33 from the control group, 91 adolescents with type 1 diabetes mellitus. All patients were between 10-18 years old and were residents of the Podillya region of Ukraine.

[The influence of acizolum to bioelements content in rat's blood plasma, parenchimal organs and brain].

Zinc content in blood plasma and brain tissue of rats was studied by analytic mass-spectrometry with inductively coupled plasma. In control (saline-treated animal) zinc content in plasma was 3.6±1.

New hydrate formation methods in a liquid-gas medium.

Conceptually new methods of hydrate formation are proposed. The first one is based on the shock wave impact on a water-bubble medium. It is shown that the hydrate formation rate in this process is typically very high.

Effects of Acyzol on Zinc Content in Rat Brain and Blood Plasma.

Zinc level in the blood plasma and brain of rats was studied by inductively coupled plasma mass spectrometry. Maximum amount of zinc was observed in the cerebellum (15.0±5.