Role of I182, R187, and K188 Amino Acid Residues in the Catalytic Domain of HIV-1 Integrase in the Processes of Reverse Transcription and Integration.

Structural organization of HIV-1 integrase is based on a tetramer formed by two protein dimers. Within this tetramer, the catalytic domain of one subunit of the first dimer interacts with the N-terminal domain of the second dimer subunit. It is the tetrameric structure that allows both ends of the viral DNA to be correctly positioned relative to the cellular DNA and to realize catalytic functions of integrase, namely 3'-processing and strand transfer.

[The analysis of potential issues of sociological research of dementia problems].

The article analyzes possibilities in sociological research of dementia and social problems it generates. In conditions of increase of unfavorable tendencies related to dementia, occurs decreasing of social status of patients and their relatives tending them, increasing of their socioeconomic maladjustment, deterioration of social and psychological well-being, stigmatization and even social isolation of individuals affected by the problem (including people working with patients with dementia). The dementia results in changes of social identity of patient and one's relatives, image, quality and standard of living.

[The social factors increasing healthy life longevity (according sociological surveys materials)].

The article discusses the main social factors that can positively effect on increasing the longevity of healthy life in the elderly. The main principles are based on the results of applied studies carried out by the authors in Moscow, Kursk, Velikiy Novgorod and Simferopol in 2019-2020. The respondents were both the elderly themselves and the specialists providing them social services support.

[The social health of family with disabled child during period of early childhood and school years].

The purpose of the study is to compare social health of families with disabled children of early childhood and school age. The social health of family with disabled child is defined as satisfaction of family members with their position in society, their opportunities for social functioning, self-realization and interaction with social institutions that ensure their social security and support, accessibility of social environment and medical and social services. The results of original sociological surveys of parents implemented in 2017 and 2020 were applied.

100 kGy gamma-affected microbial communities within the ancient Arctic permafrost under simulated Martian conditions.

This research aimed to investigate the viability and biodiversity of microbial communities within ancient Arctic permafrost after exposure to a gamma-radiation dose of 100 kGy at low temperature (- 50 °C), low pressure (1 Torr) and dehydration conditions. The main objective was to assess the possibility for long-term survival of Earth-bound microorganisms in the subsurface of Martian regolith or inside small space bodies at constant absorption and accumulation of the gamma radiation dose. Investigated microbial communities had shown high resistance to a simulated Martian environment.