MicroRNA-130b Is a Unique Autophagy-Related Epigenetic Predictor of FLOT-Chemotherapy in Gastric Cancers.

Introduction: Liquid biopsies have great potential for precision medicine as they provide information about primary and metastatic tumors using minimally invasive techniques. MicroRNAs (miRNAs) are promising biomarkers for detecting gastric cancer (GC). The aim of the study was to identify miR molecules associated with autophagy in gastric cancer (GC) cells, determine their expression levels in GC and FLOT-treated patients, and assess the efficacy of FLOT therapy in GC patients.

Blood flow dynamics in the arterial and venous parts of the capillary.

Although there is currently sufficient information on various parameters of capillary blood flow, including the average values of blood velocity, there is no data on the dynamics of velocity and the mechanisms of its modulation in various parts of the capillary. The main idea of this work is to develop a tool and image data processing to study the characteristics of the capillary blood flow dynamics. In this study, using the developed method of high-speed videocapillaroscopy, the red blood cells (RBC) velocities in the arterial and venous parts of the nailfold capillaries were compared and a time-frequency analysis of the dynamics of the velocity signals with the calculation of phase coherence was performed.

Navigating a Fine Balance: Point-Mutant Cheater Viruses Disrupt the Viral Replication Cycle.

Cheater viruses cannot replicate on their own yet replicate faster than the wild type (WT) when the 2 viruses coinfect the same cell. Cheaters must possess dual genetic features: a defect, which leads to their inability to infect cells on their own, and a selective advantage over WT during coinfection. Previously, we have discovered 2 point-mutant cheaters of the MS2 bacteriophage.

Odd-Numbered Ring Cluster Tc(μ-O)Cl(OOCCCl): Synthesis, Crystal Structure, and Optical and Thermal Properties.

Herein, we report a method for the preparation of the first odd homometallic and heterovalent nine-centered Tc wheel, [Tc(μ-O)Cl(OOCCl)]. The synthesized compound represents the pioneering instance of such clusters among d elements and is the fourth instance observed across all metals. The ring was synthesized by a solvothermal method in a solution of technetium acid in trichloroacetic anhydride.

Black Holes with Electroweak Hair.

We construct static and axially symmetric magnetically charged hairy black holes in the gravity-coupled Weinberg-Salam theory. Large black holes merge with the Reissner-Nordström (RN) family, while the small ones are extremal and support a hair in the form of a ring-shaped electroweak condensate carrying superconducting W currents and up to 22% of the total magnetic charge. The extremal solutions are asymptotically RN with a mass below the total charge, M<|Q|, due to the negative Zeeman energy of the condensate interacting with the black hole magnetic field.