Post-coordination backbone functionalization of an imidazol-2-ylidene and its application to synthesize heteropolymetallic complexes incorporating the ambidentate IMes(CO2(-)) ligand.

Backbone functionalization of the pre-coordinated, emblematic IMes ligand with the COOH moiety was achieved upon treatment of Cp(CO)2Mn(IMes) with n-BuLi followed by CO2 and HCl to afford Cp(CO)2Mn(IMes(COOH)). The latter reacts with (1,10-phen)M(OAc)2 (M = Cu, Zn) to obtain M3Mn4 polymetallic complexes exhibiting the ambidentate IMes(CO2(-)) moiety as a key structural unit.

Evaluation of a multi-arm multi-stage Bayesian design for phase II drug selection trials - an example in hemato-oncology.

Background: Multi-Arm Multi-Stage designs aim at comparing several new treatments to a common reference, in order to select or drop any treatment arm to move forward when such evidence already exists based on interim analyses. We redesigned a Bayesian adaptive design initially proposed for dose-finding, focusing our interest in the comparison of multiple experimental drugs to a control on a binary criterion measure.

Methods: We redesigned a phase II clinical trial that randomly allocates patients across three (one control and two experimental) treatment arms to assess dropping decision rules.

[Epilepsy with prolonged epileptiform activity during sleep in children and adolescents].

Benign epileptic discharges of childhood (BEDC) are typical age-related EEG patterns associated with idiopathic benign focal epilepsy (BFE). The study of BFE revealed the symptomatic phenocopies in patients with structural brain lesions in infantile cerebral paralysis and malformations. The authors discuss the question of "benignity" of BEDC that may lead to various disturbances of cognitive functions and behavior, i.