[Protective features of pore-forming proteins of pathogenic bacteria].

The paper analyzes the results of investigations of the protective properties of pore-forming proteins (porins) from pathogenic bacteria. The high immunogenicity of porins is shown to allow them to use as components of chemical vaccines to combat infectious disease pathogens against which effective agents for specific prophylaxis could not be designed. It is suggested that bacterial pore-forming proteins play the same role in the infectious process as virus-confluent proteins do and can make a ligand-receptor interaction with the eukaryotic cellular membranous surface.

[Extrachromosomal genetic elements of Clostridium botulinum. I. Plasmids of toxigenic and atoxigenic strains of Clostridium botulinum type A].

Plasmid profiles in fifteen toxigenic and six nontoxigenic strains of Clostridium botulinum type A were investigated. The electrophoretic patterns of nucleic acids from the bacterial lysates were shown to vary in relation to the mode of bacterial cells lysis and the stage of microbial population growth. Two toxigenic strains harbour a unique 3.