The Impact of Silicon Nanoparticle Porosity on Their Ability to Sensitize Low-Intensity Medical Ultrasound.

This study investigates the role of porosity in silicon nanoparticles' ability to act as sonosensitizers for sonodynamic therapy of malignant tumors. Structural analysis showed that porous nanoparticles are composed of nanocrystals approximately 4 nm in size and contain 15 nm pores, whereas non-porous nanoparticles have a dense structure with nanocrystals ranging from 10 to 50 nm. Porous nanoparticles exhibit pronounced photoluminescent properties, associated with quantum confinement effects in their small nanocrystals.

SARS-CoV-2 FP1 Destabilizes Lipid Membranes and Facilitates Pore Formation.

SARS-CoV-2 viral entry requires membrane fusion, which is facilitated by the fusion peptides within its spike protein. These predominantly hydrophobic peptides insert into target membranes; however, their precise mechanistic role in membrane fusion remains incompletely understood. Here, we investigate how FP1 (SFIEDLLFNKVTLADAGFIK), the N-terminal fusion peptide, modulates membrane stability and barrier function across various model membrane systems.

[Peculiarities of treatment with antidepressants in patients with schizoaffective disorder in the interictal period].

Objective: To investigate the effect of therapy with various classes of antidepressants on the quality of remission and adherence to therapy in patients with schizoaffective disorder (SAD) in remission.

Material And Methods: We examined 87 outpatients, including 29 men (33.33%), 58 women (66.

[Depression and it's treatment in patients with schizoaffective disorder].

Aim: To study the influence of depression on the quality of remission in patients with schizoaffective disorder (SAD) and develop recommendations for anti-relapse therapy.

Material And Methods: Eighty-nine outpatients with the diagnosis of SAD were examined, in whom 348 remission cases were studied. In accordance with the characteristics of the episodes, the patients were divided into 2 main groups: patients with only depressive manifestations (group 1) and patients with affective disorders of both poles (group 2).

Influencing the adhesion properties and wettability of mucin protein films by variation of the environmental pH.

Mucins, the main component of the mucus secretions of goblet and epithelial cells, are known for exhibiting a different behaviour in accordance with their surrounding environment (i.e. among others the environmental pH), which induces a drastic change in their measured mechanical properties.