Association between Gene Variants and Ischemic Stroke: A Pilot Study Providing Additional Evidence for the Role of Heat Shock Proteins in Disease Pathogenesis.

HSPA8 is involved in many stroke-associated cellular processes, playing a pivotal role in the protein quality control system. Here we report the results of the pilot study aimed at determining whether SNPs are linked to the risk of ischemic stroke (IS). DNA samples from 2139 Russians (888 IS patients and 1251 healthy controls) were genotyped for tagSNPs (rs1461496, rs10892958, and rs1136141) in the gene using probe-based PCR.

Polymorphism of , the gene encoding a heat-resistant obscure (Hero) protein with chaperone activity, is a novel link in ischemic stroke.

Background: Ischemic stroke (IS) is one of the most serious cardiovascular events associated with high risk of death or disability. The growing body of evidence highlights molecular chaperones as especially important players in the pathogenesis of the disease. Since six small proteins called "Hero" have been recently identified as a novel class of chaperones we aimed to evaluate whether SNP rs4644832 in gene encoding the member of Hero-proteins, is associated with the risk of IS.

SERPINE1 mRNA Binding Protein 1 Is Associated with Ischemic Stroke Risk: A Comprehensive Molecular-Genetic and Bioinformatics Analysis of SNPs.

The gene is a well-known regulator of SERPINE1 mRNA stability and progesterone signaling. However, the chaperone-like properties of have recently been discovered. The present pilot study investigated whether SNPs are associated with the risk and clinical manifestations of ischemic stroke (IS).

[Impact of effect of natural disasters on the circulation of causative agents of parasitic diseases].

The southern region is marked by a high incidence of parasitic diseases and a significant contamination of environmental objects with the eggs and cysts of their pathogens. Background examinations revealed the greatest soil contamination with helminthic eggs in the Temryuksky District of the Krasnodar Territory and in the towns of Vladikavkaz and Digora of the Republic of North Ossetia (Alania). The least contamination was found in Rostov-on-Don and the towns of the south-western area of the Krasnodar Territory.

[Effect of antithymocyte globulin on bone marrow colony-forming capacity during defective myelopoiesis].

The effect of antithymocytic globulin (ATG) on colony-forming and claster-forming capacity (CFC and ClFC) of the bone marrow in vitro was studied in patients with hypoplastic anemia. 15 children in the initial stage of the disease and 6 patients before and after splenectomy were examined. The initial CFC and ClFC of the bone marrow were 1.