Luminescence and Generation of Reactive Oxygen Species in Solution by Ta6Br12 Clusters.

An intrinsic metal cluster NIR-II emission of the {Ta6Br12}2+ aqua/hydroxocomplexes was determined in aqueous solutions under inert atmosphere. The photoluminescence (PL) is enhanced in D2O, and the lifetime scale expands from nanoseconds to microseconds. Possible cluster emission transitions have been assigned and analyzed from a computational perspective.

Raman-Enabled Predictions of Protein Content and Metabolites in Biopharmaceutical Fermentations.

Raman spectroscopy, a robust and non-invasive analytical method, has demonstrated significant potential for monitoring biopharmaceutical production processes. Its ability to provide detailed information about molecular vibrations makes it ideal for the detection and quantification of therapeutic proteins and critical control parameters in complex biopharmaceutical mixtures. However, its application in fermentations has been hindered by the inherent strong fluorescence background from the cells.

Unilateral Sensorineural Hearing Loss in Congenital Cytomegalovirus Retrospective Observational Study.

Background: The leading nonhereditary cause of childhood sensorineural hearing loss has been attributed to congenital cytomegalovirus (cCMV). Sensorineural hearing loss can be unilateral (UHL) or bilateral (BHL), and may be progressive. Our objective was to describe the characteristics, clinical nature and follow-up of ears in cCMV-associated UHL.

Therapeutic potential of archaeal unfoldase PANet and the gateless T20S proteasome in P23H rhodopsin retinitis pigmentosa mice.

Neurodegenerative diseases are characterized by the presence of misfolded and aggregated proteins which are thought to contribute to the development of the disease. In one form of inherited blinding disease, retinitis pigmentosa, a P23H mutation in the light-sensing receptor, rhodopsin causes rhodopsin misfolding resulting in complete vision loss. We investigated whether a xenogeneic protein-unfolding ATPase (unfoldase) from thermophilic Archaea, termed PANet, could counteract the proteotoxicity of P23H rhodopsin.

Discrete Hexa- and Binuclear Heterometallic Iodobismuthate(III) Complexes with Cu(I) and Ag(I).

The rare examples of discrete anionic halobismuthates(III) with group 11 elements were obtained. Those are (3-MePyH)[BiCuI] () and (3,5-MePyC)[BiAgI] () (3-MePyH = 3-methylpyridinium cation, 3,5-MePyC=1,6-bis(3,5-dimethylpyridinium)hexane dication). Both complexes were isolated as pure phases; the optical band gaps for and are 1.