Publications by authors named "M V Sharakhova"
Insects can adapt quickly and effectively to rapid environmental change and maintain long-term adaptations, but the genetic mechanisms underlying this response are not fully understood. In this review, we summarize studies on the potential impact of chromosomal inversion polymorphisms on insect evolution at different spatial and temporal scales, ranging from long-term evolutionary stability to rapid emergence in response to emerging biotic and abiotic factors. The study of inversions has recently been advanced by comparative, population, and 3D genomics methods.
View Article and Find Full Text PDFBackground: Understanding genome organization and evolution is important for species involved in transmission of human diseases, such as mosquitoes. Anophelinae and Culicinae subfamilies of mosquitoes show striking differences in genome sizes, sex chromosome arrangements, behavior, and ability to transmit pathogens. However, the genomic basis of these differences is not fully understood.
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- Detailed study of phylogeography is crucial for managing mosquito species that spread diseases like malaria, particularly focusing on the two related species, Anopheles messeae and An. daciae.
- The research used ribosomal DNA analysis and karyotyping across 28 Eurasian locations to uncover genetic diversity and population structure, highlighting significant differences in their chromosomes and indicating limited gene flow between the species.
- Findings suggest that An. messeae has a more complex genetic makeup than An. daciae, with implications for understanding malaria transmission risk in various regions, particularly in northern Europe.
Article Synopsis
- The study focuses on the phylogenetic relationships of malaria-carrying mosquitoes in the Maculipennis Group, examining how their traits and evolutionary history affect disease transmission.
- Phylogenomic analysis of 13 mosquito species revealed that the Palearctic species An. beklemishevi clusters with Eurasian species and showed closer ties to An. freeborni from North America than to An. quadrimaculatus.
- Migration patterns suggest that these mosquitoes moved from North America to Eurasia around 20-25 million years ago, with significant genetic exchanges occurring between isolated species, impacting their traits and adaptations.
Visualization of the Linear and Spatial Organization of Chromosomes in Mosquitoes.
Cold Spring Harb Protoc
December 2022
Mosquitoes are vectors of dangerous human diseases such as malaria, dengue, Zika, West Nile fever, and lymphatic filariasis. Visualization of the linear and spatial organization of mosquito chromosomes is important for understanding genome structure and function. Utilization of chromosomal inversions as markers for population genetics studies yields insights into mosquito adaptation and evolution.
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