Skin Hydration by Natural Moisturizing Factors, a Story of H-Bond Networking.

Dry skin is a common condition that is experienced by many. Besides being particularly present during the cold season, various diseases exist all year round, leading to localized xerosis. To prevent it, the skin is provided with natural moisturizing factors (NMFs).

Low-coordinate bis-phosphine and monophosphine Ni(0) complexes: synthesis and reactivity in C-S cross-coupling.

Preformed Ni(0) complexes are rarely used as precatalysts in cross-coupling reactions, although they can incorporate catalytically active nickel directly into the reaction. In this work, we focus on the preparation and the catalytic application of low-coordinate Ni(0) complexes supported by bulky monophosphine ligands in C-S cross-coupling reactions. We have prepared two families of Ni(0) complexes, bis-phosphine aducts of the type [Ni(PRAr')] (Ar' = -terphenyl group) and monophosphine derivatives of the type [Ni(PRAr')(DVDS)] (DVDS = divinyltetramethyldisiloxane).

Patient experience, understanding and self-management of asthma attacks: a qualitative study.

Rationale: Asthma attacks (AA) are potentially life-threatening complications of asthma associated with high levels of morbidity, mortality and rising healthcare costs. Patient experience, impact and understanding of AA is poorly described in the literature. Enhanced understanding will identify unmet needs in asthma care and support the development of improved personalized strategies for managing and preventing attacks.

HCMV infection downregulates GPX4 and stimulates lipid peroxidation but does not induce ferroptosis.

Unlabelled: Human cytomegalovirus (HCMV) modulates numerous cellular pathways to facilitate infection, including key components in cellular iron homeostasis. Iron is essential to many cellular processes but, if present in excess, drives cell death through ferroptosis. Ferroptosis is a process that is dependent upon the accumulation of oxidatively damaged phospholipids (lipid peroxides); when these lipid peroxides accumulate in membranes, this culminates in plasma membrane rupture and eventual cell lysis.

Effects of Phytochemicals on Metabolic Diseases and Human Health.

Metabolic diseases constitute a worldwide health concern because of their increasing prevalence and associated mortality [...