Publications by authors named "M V S Ramarao"
Article Synopsis
- - Heatwaves in Latin America are expected to become more frequent, longer, and more intense by mid-century, with even greater increases under the high emissions scenario (RCP8.5) compared to the low emissions scenario (RCP2.6).
- - The frequency of heatwaves may double across most of Latin America, leading to a significant increase in population exposure to extreme heat, projected to rise by three to ten times in Central and South America.
- - Following a low emissions pathway (RCP2.6) could significantly reduce heatwave exposure—by 57% in Central America and 50% in South America—emphasizing the need for emissions control and sustainable practices to mitigate climate change impacts. *
Severe air pollution and foggy conditions during winter are persistent challenges, pose significant health hazards, and disrupt daily routines worldwide. In this study, we have investigated the conditions favoring the prolonged fog events in Delhi during January 2024 using observations, back trajectories, and reanalysis datasets. Analysis of visibility observations reveals that foggy (54, 121, 139, and 372 half-hours of very dense, dense, moderate, and shallow fog, respectively) conditions persisted in Delhi for 46 % of the time during the study period.
View Article and Find Full Text PDFRecent literature reports highlight the importance of the renal outer medullary potassium (ROMK) channel in renal sodium and potassium homeostasis and emphasize the potential impact that ROMK inhibitors could have as a novel mechanism diuretic in heart failure patients. A series of piperazine-based ROMK inhibitors were designed and optimized to achieve excellent ROMK potency, hERG selectivity, and ADME properties, which led to the identification of compound (BMS-986308). BMS-986308 demonstrated efficacy in the volume-loaded rat diuresis model as well as promising in vitro and in vivo profiles and was therefore advanced to clinical development.
View Article and Find Full Text PDFDiverse dopamine (DA) pathways send distinct reinforcement signals to different striatal regions. In adult songbirds, a DA pathway from the ventral tegmental area (VTA) to Area X, the striatal nucleus of the song system, carries singing-related performance error signals important for learning. Meanwhile, a parallel DA pathway to a medial striatal area (MST) arises from a distinct group of neighboring DA neurons that lack connectivity to song circuits and do not encode song error.
View Article and Find Full Text PDFArticle Synopsis
- Recent studies on mice suggest that AAK1 could be a promising target for treating neuropathic pain, which led to the development of a new drug called BMS-986176/LX-9211 that is currently in phase II trials.
- Researchers also discovered additional highly selective and effective AAK1 inhibitors through structure-activity relationship studies, which showed promising results in neuropathic pain models with strong ability to penetrate the CNS.
- Among these compounds, one central pyridine isomer proved to be four times more potent than BMS-986176/LX-9211 with better efficacy but had a less favorable toxicity profile in preclinical tests.