[Changes of retinal neurons and Muller glial cells in patients with type II diabetes in treatment of diabetic retinopathy with angiotensin-converting enzyme inhibitor].

Flicker-ERG (FERG) amplitude and glial indices Cg were measured to estimate angiotensin- converting enzyme (ACE) inhibitor Perindopril effect on retinal glial-neuronal interactions in patients with type II diabetes and diabetic retinopathy (DR). Intake of 5 mg Perindopril daily during 2 months improved photoreceptor and bipolar cells function in all stages of DR with the most significant effect in preproliferative DR (PPDR). After treatment course initially supernormal FERG scotopic glial indices reduced by 8,3-12 Hz (25-33%) in nonproliferative DR and PPDR and by 10% in proliferative DR.

[Metastatic choroidal carcinoma. Two clinical cases].

Presented clinical cases show significance of up-to-date diagnostic techniques (fluorescence angiography and spectral domain optical coherence tomography) in confirmation of metastatic choroidal carcinoma diagnosis in one case and in contradiction in another and appropriate treatment prescription.

[Ocular blood flow assessment in normal subjects and in patients with hyperglycemia based on the results of ultrasonic examination in experiment].

Scheme of ocular blood flow in rats was developed and main blood flow parameters were studied using color Doppler mapping, energetic mapping and impulse Doppler ultrasonography. Features of ocular blood flow changes are revealed in experimental model of streptozotocin induced diabetes mellitus during 12 months of follow-up. Inferior ophthalmic artery showed the most significant changes.

[Differential diagnosis of early central choroidal melanoma and late stage age-related macula degeneration].

Clinical signs characteristic for early central choroidal melanoma (42 patients) and late stage age-related macula degeneration according to AREDS (47 patients) were determined in 89 patients. These signs allow to differentiate between tumor and degenerative process thus providing appropriate treatment.

[Eye blood flow and its changes in patients with diabetes mellitus].

The main characteristics of retinal blood flow are presented including vessel diameter blood velocity, blood flow, perfusion pressure, indices of vasoresistance. The main methods of eye blood flow and retinal circulation examination are described. Comparative estimation of different techniques for eye haemodynamics examination in patients with diabetes mellitus is presented.