A rare familial rearrangement of chromosomes 9 and 15 associated with intellectual disability: a clinical and molecular study.

Background: There are many reports on rearrangements occurring separately in the regions of chromosomes 9p and 15q affected in the case under study. 15q duplication syndrome is caused by the presence of at least one extra maternally derived copy of the Prader-Willi/Angelman critical region. Trisomy 9p is the fourth most frequent chromosome anomaly with a clinically recognizable syndrome often accompanied by intellectual disability.

Possible role and application of fMRI in the screening of release-active drugs.

Functional magnetic resonance imaging (fMRI) of the brain was applied for preclinical evaluation of the efficiency of Divaza preparation intended for the treatment of cerebrovascular disorders. Psychological testing (Stroop task) in the magnetic field of fMRI was performed before and after 12-week treatment course using a double blind placebo-controlled protocol. It was shown that standard psychological and neuropsychological protocols do not allow fully estimate the results of treatment, whereas fMRI targeted the pool of cerebral structures activated during task solution.

Dynamic mapping of the brain in substance-dependent individuals: functional magnetic resonance imaging.

Functional magnetic resonance imaging can be used to study numerous brain dysfunctions, including disorders of the self, in substance-dependent individuals. The self as the sum of human concepts about oneself is regulated by the brain system close to the default mode network: the medial prefrontal cortex, posterior cingulated gyrus, and some parietal regions. However, the composition and activity of this system in mental disease, specifically, in substance addiction, are virtually not described.

Trace effects of game biofeedback: functional MRI study.

We studied the intracerebral dynamics of developing skills for self-regulation of psychophysiological functions in the biofeedback game model via functional MRI. Multiple game plots managed by physiological characteristics leave a trace in the form of activity zones in the middle occipital gyrus, middle temporal gyrus, middle frontal gyrus, inferior parietal lobule, and declive functionally related to cognitive actions and operations. During the development of self-regulation skills, the gradual shift of the localization of areas of activity is observed towards sensory projection fields (e.