Lyophilized ash gourd ( (Thunb.) Cogn.) juice alleviates diet-induced prediabetes in a rat model.

Prediabetes is characterized by elevated blood sugar levels, indicating an increased risk of developing diabetes. This study evaluated the effects of ash gourd (AG), a tropical fruit from the Cucurbitaceae family, on prediabetes, as well as its phytochemical composition. A prediabetic rat model was developed in Sprague-Dawley (SD) rats by administering a high fat diet (HFD) for 16 weeks.

Identification of heptonic acid γ-lactone by its unusual peracetylated derivative from .

The methanolic extract of was peracetylated to obtain an unusual peracetylated γ-lactone backbone. Structure elucidation revealed that this compound is an outcome of the chemical transformation of heptonic acid γ-lactone.

Peracetylation transforms natural products beyond mere derivatization.

Peracetylation of the methanolic extract of led to the isolation of a compound with a peracetylated hex-4-en-3-one backbone. Mechanistic insights revealed that the isolated compound is an outcome of the chemical transformation of a α-dicarbonyl compound.

Molecular biomarkers NOTCH1, CD44, BMI1, and TP53 in oral squamous cell carcinoma.

It is of interest to evaluate NOTCH1, CD44, BMI1, and TP53 genes in the epiglottis, tongue, and hard palate of oral malignancies (OM) with healthy controls. This was a prospective and cross-sectional study of 60 individuals with oral malignancies (OM) (20 each of tongue, epiglottis, and hard palate) studied at Malla Reddy Medical College and tertiary care hospitals in Hyderabad. Adults aged ≥ 18 years and diagnosed with oral cancer were included in the study.

Artifacts from the methanolic extract of Linn.

Two new lactones, γ-butyrolactone and δ-valerolactone were isolated from the methanolic extract of . Structure elucidation was carried out by exhaustive 2D NMR analysis. The structures of the lactones depict the outcome of their isolation as a situation that involve the formation of artifacts.